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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.

Cell metabolism | Sep 5, 2017

Calorie restriction, without malnutrition, has been shown to increase lifespan and is associated with a shift away from glycolysis toward beta-oxidation. The objective of this study was to mimic this metabolic shift using low-carbohydrate diets and to determine the influence of these diets on longevity and healthspan in mice. C57BL/6 mice were assigned to a ketogenic, low-carbohydrate, or control diet at 12 months of age and were either allowed to live their natural lifespan or tested for physiological function after 1 or 14 months of dietary intervention. The ketogenic diet (KD) significantly increased median lifespan and survival compared to controls. In aged mice, only those consuming a KD displayed preservation of physiological function. The KD increased protein acetylation levels and regulated mTORC1 signaling in a tissue-dependent manner. This study demonstrates that a KD extends longevity and healthspan in mice.

Pubmed ID: 28877457 RIS Download

Mesh terms: Acetylation | Adaptation, Physiological | Animals | Diet, Carbohydrate-Restricted | Diet, Ketogenic | Health | Longevity | Male | Mechanistic Target of Rapamycin Complex 1 | Mice, Inbred C57BL | Organ Specificity | Signal Transduction

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Associated grants

  • Agency: NIA NIH HHS, Id: P01 AG025532
  • Agency: NIDDK NIH HHS, Id: U24 DK092993
  • Agency: NIDDK NIH HHS, Id: U2C DK092993
  • Agency: NIH HHS, Id: U42 OD012210

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MMPC-University of California Davis

Center that provides the scientific community with metabolic and physiologic phenotyping tests, services, and procedures for mouse models of diabetes, diabetic complications, obesity and related disorders in order to advance medical and biological research.

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