Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories.

Cell | 2017

The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells) by a common set of neural circuits, but this hypothesis has not been established. The medial temporal-lobe system is essential for the formation and retrieval of episodic memory for which individual hippocampal subfields and entorhinal cortex layers contribute by carrying out specific functions. One subfield whose function is poorly known is the subiculum. Here, we show that dorsal subiculum and the circuit, CA1 to dorsal subiculum to medial entorhinal cortex layer 5, play a crucial role selectively in the retrieval of episodic memories. Conversely, the direct CA1 to medial entorhinal cortex layer 5 circuit is essential specifically for memory formation. Our data suggest that the subiculum-containing detour loop is dedicated to meet the requirements associated with recall such as rapid memory updating and retrieval-driven instinctive fear responses.

Pubmed ID: 28823555 RIS Download

Mesh terms: Animals | Corticosterone | Entorhinal Cortex | Gene Expression | Hippocampus | Male | Memory, Episodic | Mice | Mice, Inbred C57BL | Neural Pathways | Neurons | Optogenetics

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


Microsoft Excel (tool)

RRID:SCR_016137

Software application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.

View all literature mentions

Anti-VGLUT 2 antibody (antibody)

RRID:AB_887883

This polyclonal antibody targets VGLUT 2

View all literature mentions

CaMKII antibody [6G9] (antibody)

RRID:AB_447192

This monoclonal antibody targets CaMKII

View all literature mentions

Goat anti-Rabbit IgG (H+L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 546 (antibody)

RRID:AB_2534077

This polyclonal antibody targets Rabbit IgG (H+L) Cross-Adsorbed

View all literature mentions

Monoclonal anti Calbindin D-28k antibody (antibody)

RRID:AB_10000347

This monoclonal antibody targets Calbindin D-28k

View all literature mentions

Anti-Vesicular Glutamate Transporter 3 (VGLUT3) antibody (antibody)

RRID:AB_2187832

This polyclonal antibody targets Vesicular Glutamate Transporter 3 (VGLUT3)

View all literature mentions

GFP Tag Antibody (antibody)

RRID:AB_2534023

This polyclonal antibody targets GFP Tag

View all literature mentions

Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 555 (antibody)

RRID:AB_2535850

This polyclonal antibody targets Rabbit IgG (H+L) Highly Cross-Adsorbed

View all literature mentions

Anti-NeuN antibody (antibody)

RRID:AB_2298772

This monoclonal antibody targets NeuN

View all literature mentions

Monoclonal anti Parvalbumin antibody (antibody)

RRID:AB_10000343

This monoclonal antibody targets parvalbumin

View all literature mentions

Anti-GAD67 antibody (antibody)

RRID:AB_2278725

This monoclonal antibody targets GAD67

View all literature mentions

WFS1 antibody (antibody)

RRID:AB_2216046

This polyclonal antibody targets WFS1

View all literature mentions

GraphPad Prism (tool)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

View all literature mentions

ImageJ (tool)

RRID:SCR_003070

Software tool as an open source Java-based image processing program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

View all literature mentions

MATLAB (tool)

RRID:SCR_001622

Multi paradigm numerical computing environment and fourth generation programming language developed by MathWorks. Allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. Used to explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

View all literature mentions

EthoVision XT (tool)

RRID:SCR_000441

Video tracking software that tracks and analyzes the behavior, movement, and activity of any animal.

View all literature mentions