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A major hurdle for functional recovery after both spinal cord injury and cortical stroke is the limited regrowth of the axons in the corticospinal tract (CST) that originate in the motor cortex and innervate the spinal cord. Despite recent advances in engaging the intrinsic mechanisms that control CST regrowth, it remains to be tested whether such methods can promote functional recovery in translatable settings. Here we show that post-lesional AAV-assisted co-expression of two soluble proteins, namely insulin-like growth factor 1 (IGF1) and osteopontin (OPN), in cortical neurons leads to robust CST regrowth and the recovery of CST-dependent behavioral performance after both T10 lateral spinal hemisection and a unilateral cortical stroke. In these mice, a compound able to increase axon conduction, 4-aminopyridine-3-methanol, promotes further improvement in CST-dependent behavioral tasks. Thus, our results demonstrate a potentially translatable strategy for restoring cortical dependent function after injury in the adult.
Pubmed ID: 28817801 RIS Download
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View all literature mentionsThis polyclonal targets VGLUT 1
View all literature mentionsThis monoclonal targets CD68
View all literature mentionsThis monoclonal targets Phospho-S6 Ribosomal Protein (Ser235/236)
View all literature mentionsThis monoclonal targets Phospho-IGF-I Receptor beta (Tyr1135/1136)/Insulin Receptor beta (Tyr1150/1151) (19H7) Rabbit mAb
View all literature mentionsThis polyclonal targets IGF1R
View all literature mentionsThis polyclonal targets Serotonin
View all literature mentionsThis polyclonal targets PKC gamma (C-19)
View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsThis polyclonal targets RFP (Biotin)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsMus musculus with name C57BL/6NCrl from IMSR.
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