Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Publication

Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade.

Cancer cell | 2017

Glioblastoma is an immunosuppressive, fatal brain cancer that contains glioblastoma stem-like cells (GSCs). Oncolytic herpes simplex virus (oHSV) selectively replicates in cancer cells while inducing anti-tumor immunity. oHSV G47Δ expressing murine IL-12 (G47Δ-mIL12), antibodies to immune checkpoints (CTLA-4, PD-1, PD-L1), or dual combinations modestly extended survival of a mouse glioma model. However, the triple combination of anti-CTLA-4, anti-PD-1, and G47Δ-mIL12 cured most mice in two glioma models. This treatment was associated with macrophage influx and M1-like polarization, along with increased T effector to T regulatory cell ratios. Immune cell depletion studies demonstrated that CD4+ and CD8+ T cells as well as macrophages are required for synergistic curative activity. This combination should be translatable to the clinic and other immunosuppressive cancers.

Pubmed ID: 28810147 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

None found

Antibodies used in this publication

Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA160762
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS032677

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

CD68 antibody (antibody)

RRID:AB_10975465

This polyclonal targets CD68 antibody

View all literature mentions

Anti-PD-L1 Antibody (antibody)

RRID:AB_2687878

This monoclonal targets PD-L1

View all literature mentions

Brilliant Violet 605(TM) anti-mouse/human CD11b (antibody)

RRID:AB_11126744

This monoclonal targets CD11b

View all literature mentions

PE/Cyanine7 anti-mouse CD152 (antibody)

RRID:AB_2564237

This monoclonal targets CD152

View all literature mentions

InVivoPlus anti-mouse PD-L1 (B7-H1) (antibody)

RRID:AB_10949073

This monoclonal targets PD-L1 (B7-H1)

View all literature mentions

iNOS antibody (antibody)

RRID:AB_301857

This polyclonal targets iNOS antibody

View all literature mentions

Recombinant Anti-Ki67 antibody [SP6] (antibody)

RRID:AB_302459

This recombinant monoclonal targets Ki67

View all literature mentions

Rabbit Anti-Mouse FOXP3 Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_880110

This polyclonal targets Mouse FOXP3

View all literature mentions

Anti-CD3 antibody (antibody)

RRID:AB_305055

This polyclonal targets CD3

View all literature mentions

Alexa Fluor(R) 647 anti-mouse FOXP3 (antibody)

RRID:AB_1089116

This monoclonal targets FOXP3

View all literature mentions

ImmPRESS-AP Anti-Rabbit Ig Reagent (antibody)

RRID:AB_2336536

This unknown targets IgG

View all literature mentions

ImmPRESS® HRP Horse Anti-Rabbit IgG Polymer Detection Kit, Peroxidase (antibody)

RRID:AB_2336529

This unknown targets IgG

View all literature mentions

ImmPRESS Anti-Rat Ig (Mouse Adsorbed) Reagent (antibody)

RRID:AB_2336530

This unknown targets IgG

View all literature mentions

F4/80 antibody [SP115] (antibody)

RRID:AB_10859466

This monoclonal targets F4/80 antibody [SP115]

View all literature mentions

T-bet / Tbx21 antibody [4B10] (antibody)

RRID:AB_2050371

This monoclonal targets T-bet / Tbx21 antibody [4B10]

View all literature mentions

Rabbit Anti-Stat1, phospho (Tyr701) Monoclonal Antibody, Unconjugated, Clone 58D6 (antibody)

RRID:AB_561284

This monoclonal targets Stat1, phospho (Tyr701)

View all literature mentions

Cleaved Caspase-3 (Asp175) Antibody (antibody)

RRID:AB_2341188

This polyclonal targets Cleaved Caspase-3 (Asp175)

View all literature mentions

Granzyme B antibody (antibody)

RRID:AB_304251

This polyclonal targets Granzyme B

View all literature mentions

CD8a Monoclonal Antibody (4SM15), eBioscience (antibody)

RRID:AB_2572860

This monoclonal targets CD8a

View all literature mentions

CD4 Monoclonal Antibody (4SM95), eBioscience (antibody)

RRID:AB_2573007

This monoclonal targets CD4

View all literature mentions

Alexa Fluor(R) 700 anti-mouse Ly-6G/Ly-6C (Gr-1) (antibody)

RRID:AB_493728

This monoclonal targets Ly-6G Ly-6C

View all literature mentions

PE/Cyanine7 anti-mouse CD69 (antibody)

RRID:AB_493565

This monoclonal targets CD69

View all literature mentions

APC anti-mouse F4/80 (antibody)

RRID:AB_893493

This monoclonal targets F4/80

View all literature mentions

APC anti-mouse CD279 (PD-1) (antibody)

RRID:AB_2251944

This monoclonal targets CD279

View all literature mentions

Brilliant Violet 421(TM) anti-mouse CD274 (B7-H1, PD-L1) (antibody)

RRID:AB_10897097

This monoclonal targets CD274

View all literature mentions

Alexa Fluor(R) 700 anti-mouse CD45 (antibody)

RRID:AB_493714

This monoclonal targets CD45

View all literature mentions

Brilliant Violet 421(TM) anti-mouse CD31 (antibody)

RRID:AB_2562186

This monoclonal targets CD31

View all literature mentions

Brilliant Violet 510(TM) anti-mouse CD8a (antibody)

RRID:AB_2561389

This monoclonal targets CD8a

View all literature mentions

PerCP/Cyanine5.5 anti-mouse CD4 (antibody)

RRID:AB_893330

This monoclonal targets CD4

View all literature mentions

APC/Cyanine7 anti-mouse CD3epsilon (antibody)

RRID:AB_1877171

This monoclonal targets CD3epsilon

View all literature mentions

InVivoPlus polyclonal Syrian hamster IgG (antibody)

RRID:AB_1107782

This isotype control targets Unknown Specificity

View all literature mentions

rat IgG2b I sotype control (antibody)

RRID:AB_1107780

This isotype control targets KLH

View all literature mentions

anti-mouse CD8α (antibody)

RRID:AB_1125541

This monoclonal targets CD8α

View all literature mentions

anti-mouse CD4 (antibody)

RRID:AB_1107636

This monoclonal targets CD4

View all literature mentions

InVivoPlus anti-mouse CTLA-4 (CD152) (antibody)

RRID:AB_10950184

This monoclonal targets CTLA-4 (CD152)

View all literature mentions

InVivoPlus anti-mouse PD-1 (CD279) (antibody)

RRID:AB_10949053

This monoclonal targets PD-1 (CD279)

View all literature mentions

PerCP/Cyanine5.5 anti-mouse I-A/I-E (antibody)

RRID:AB_2191072

This monoclonal targets I-A/I-E

View all literature mentions

APC anti-human CD274 (B7-H1, PD-L1) (antibody)

RRID:AB_940358

This monoclonal targets CD274

View all literature mentions

APC anti-mouse CD274 (B7-H1, PD-L1) (antibody)

RRID:AB_10612935

This monoclonal targets CD274

View all literature mentions

Vero (cell line)

RRID:CVCL_0059

Cell line Vero is a Spontaneously immortalized cell line with a species of origin Chlorocebus sabaeus

View all literature mentions

CD68 antibody (antibody)

RRID:AB_10975465

This polyclonal targets CD68 antibody

View all literature mentions

PerCP/Cyanine5.5 anti-mouse I-A/I-E (antibody)

RRID:AB_2191072

This monoclonal targets I-A/I-E

View all literature mentions

About

The SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.

Recent News Entries

New Release: NeuroMorpho.Org Version 8.6 (12/4/23), with 14,452 new tracings from 45 datasets

Dr. Martone on BrainFacts.org a FAIR video

With 2023 there are new NIH guidelines on data deposition, are you ready?

Contact Us

FAIR Data Informatics Lab

University of California, San Diego
9500 Gilman Drive, Mail Code 0608
La Jolla, CA 92093-0608
United States

info  scicrunch.org

About SciCrunch | Privacy Policy | Terms of Service

SciCrunch