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Publication

Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.

Cell | 2017

Lower urinary tract infections are among the most common human bacterial infections, but extension to the kidneys is rare. This has been attributed to mechanical forces, such as urine flow, that prevent the ascent of bladder microbes. Here, we show that the regional hypersalinity, required for the kidney's urine-concentrating function, instructs epithelial cells to produce chemokines that localize monocyte-derived mononuclear phagocytes (MNPs) to the medulla. This hypersaline environment also increases the intrinsic bactericidal and neutrophil chemotactic activities of MNPs to generate a zone of defense. Because MNP positioning and function are dynamically regulated by the renal salt gradient, we find that patients with urinary concentrating defects are susceptible to kidney infection. Our work reveals a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.

Pubmed ID: 28803730 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

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Antibodies used in this publication

Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: MR/K023934/1
  • Agency: Medical Research Council, United Kingdom
    Id: MR/N024907/1

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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Anti-MCP1 antibody [EP1361] (antibody)

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Ki-67 Monoclonal Antibody (SolA15), PE, eBioscience (antibody)

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Rabbit Anti-Green Fluorescent Protein (GFP) Polyclonal Antibody, Alexa Fluor ?? 488 Conjugated (antibody)

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Anti-rabbit IgG (H+L) (DyLight 800 Conjugate) (antibody)

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Anti-rabbit IgG (H+L) (DyLight 680 Conjugate) (antibody)

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CX3CL1 antibody (antibody)

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Donkey anti-Rabbit IgG (H+L) ReadyProbes Secondary Antibody, Alexa Fluor™ 488 (antibody)

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beta Actin Loading Control Monoclonal Antibody (BA3R) (antibody)

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BUV395 Rat Anti-Mouse CD45 Clone 30-F11 (RUO) (antibody)

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E. coli antibody (FITC) (antibody)

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Alexa Fluor(R) 488 anti-mouse/human CD11b (antibody)

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Brilliant Violet 650(TM) anti-mouse CX3CR1 (antibody)

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Rabbit Anti-Mouse MIP-2 Polyclonal antibody, Biotin Conjugated (antibody)

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TNF alpha Monoclonal Antibody (MP6-XT22), PE, eBioscience (antibody)

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IL-6 Monoclonal Antibody (MP5-20F3), PE, eBioscience (antibody)

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F4/80 Monoclonal Antibody (BM8), APC, eBioscience™ (antibody)

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F4/80 Monoclonal Antibody (BM8), FITC, eBioscience (antibody)

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MHC Class II (I-A/I-E) Monoclonal Antibody (M5/114.15.2), Alexa Fluor™ 700, eBioscience (antibody)

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CD11c Monoclonal Antibody (N418), PE-Cyanine7, eBioscience (antibody)

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This monoclonal targets Ly-6G/Ly-6C

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Anti-Mouse CD19 eFluor® 450 100 ug Antibody (antibody)

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CD3 Monoclonal Antibody (17A2), eFluor™ 450, eBioscience (antibody)

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CD45.2 Monoclonal Antibody (104), APC-eFluor™ 780, eBioscience (antibody)

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Anti-Human Langerin Monoclonal Antibody, Phycoerythrin Conjugated, Clone 343828 (antibody)

RRID:AB_2074215

This monoclonal targets Human Langerin

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NFAT5 Polyclonal Antibody (antibody)

RRID:AB_2152617

This unknown targets NFAT5

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APC anti-human CD191 (CCR1) (antibody)

RRID:AB_2563919

This monoclonal targets CD191

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APC anti-mouse CD68 (antibody)

RRID:AB_10575300

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Alexa Fluor(R) 700 anti-human CD19 (antibody)

RRID:AB_493751

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Alexa Fluor(R) 700 anti-human CD15 (SSEA-1) (antibody)

RRID:AB_2561427

This monoclonal targets CD15

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Alexa Fluor(R) 700 anti-human CD3 (antibody)

RRID:AB_493741

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CD1c (BDCA-1)-PE (antibody)

RRID:AB_244315

This monoclonal targets Non-Human Primate CD1c (BDCA-1)

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CD1a Antibody, PE (antibody)

RRID:AB_2656020

This monoclonal targets CD1a

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APC anti-human CD193 (CCR3) (antibody)

RRID:AB_2228976

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Brilliant Violet 650(TM) anti-human CD15 (SSEA-1) (antibody)

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FITC anti-human IL-8 (antibody)

RRID:AB_893462

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APC anti-human CD192 (CCR2) (antibody)

RRID:AB_2562239

This monoclonal targets CD192

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Brilliant Violet 650(TM) anti-human CD14 (antibody)

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CD197 (CCR7) Monoclonal Antibody (3D12), PE-Cyanine7, eBioscience (antibody)

RRID:AB_2573422

This monoclonal targets CD197 (CCR7)

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CD195 (CCR5) Monoclonal Antibody (NP-6G4), APC, eBioscience (antibody)

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CD8a Monoclonal Antibody (HIT8a), PE, eBioscience (antibody)

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CD172a (SIRP alpha) Monoclonal Antibody (15-414), APC, eBioscience (antibody)

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CD209 (DC-SIGN) Monoclonal Antibody (eB-h209), PE, eBioscience (antibody)

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CD16 Monoclonal Antibody (eBioCB16 (CB16)), PE-Cyanine7, eBioscience (antibody)

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CD64 Monoclonal Antibody (10.1), APC, eBioscience (antibody)

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CD11b Monoclonal Antibody (C67F154), Alexa Fluor™ 488, eBioscience (antibody)

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CD206 (MMR) Monoclonal Antibody (19.2), Alexa Fluor™ 488, eBioscience (antibody)

RRID:AB_2574416

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IL-6 Monoclonal Antibody (MQ2-13A5), PE-Cyanine7, eBioscience (antibody)

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TNF alpha Monoclonal Antibody (MAb11), PE, eBioscience (antibody)

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CX3CR1 Monoclonal Antibody (2A9-1), PE, eBioscience (antibody)

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CD11c Monoclonal Antibody (3.9), PE-Cyanine7, eBioscience (antibody)

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HLA-DR Monoclonal Antibody (L243), eFluor™ 450, eBioscience (antibody)

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CD45 PerCP-Cy5.5 120 tests (antibody)

RRID:AB_11182108

This monoclonal targets CD45 PerCP-Cy5.5 120 tests

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CD45 Monoclonal Antibody (2D1), PE, eBioscience (antibody)

RRID:AB_10718238

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B6.129S4-Ccr2tm1Ifc/J (organism)

RRID:IMSR_JAX:004999

Mus musculus with name B6.129S4-Ccr2tm1Ifc/J from IMSR.

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C.Cg-Tg(Itgax-Venus)1Mnz/J (organism)

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Mus musculus with name C.Cg-Tg(Itgax-Venus)1Mnz/J from IMSR.

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C57BL/6-Tg(UBC-GFP)30Scha/J (organism)

RRID:IMSR_JAX:004353

Mus musculus with name C57BL/6-Tg(UBC-GFP)30Scha/J from IMSR.

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C57BL/6J (organism)

RRID:IMSR_JAX:000664

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HK-2 [Human kidney] (cell line)

RRID:CVCL_0302

Cell line HK-2 [Human kidney] is a Transformed cell line with a species of origin Homo sapiens (Human)

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Anti-MCP1 antibody [EP1361] (antibody)

RRID:AB_2687891

This monoclonal targets MCP1

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Anti-MCP1 antibody [EP1361] (antibody)

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