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It has been proposed that the deficit in β-cell mass in type 1 diabetes (T1D) may be due, in part, to β-cell degranulation to chromogranin-positive hormone-negative (CPHN) cells. The frequency and distribution of pancreatic CPHN cells were investigated in 19 children with T1D compared with 14 non-diabetic (ND) children. We further evaluated these cells for replication and expression of endocrine lineage markers Nkx6.1 and Nkx2.2, and compared these frequencies with those previously reported in CPHN cells in adults with T1D. In contrast to adults' cells, pancreatic CPHN cells were comparably abundant (percentage of endocrine cells ± standard error of the mean, 1.4 ± 0.2 vs 1.0 ± 0.2 in patients with T1D vs ND subjects, respectively; P = not significant) and comparably distributed in children with T1D vs ND donors. Replication of CPHN cells was detected but unchanged in children with T1D vs ND children, as was the percentage of CPHN cells expressing Nkx6.1 or NKx2.2. In children with T1D, the frequency of pancreatic CPHN cells was not increased, and this differed from adults with T1D.
Pubmed ID: 28782056 RIS Download
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View all literature mentionsA software package for performing 2D microscope image processing and integrating and controlling a diverse array of instrumentation in a laboratory environment. The software suite has four basic areas of operation acquisition, image presentation, and storage, analysis, and automation.
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View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets
View all literature mentionsThis monoclonal targets Ghrelin peptides
View all literature mentionsThis monoclonal targets Somatostatin
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View all literature mentionsThis monoclonal targets Glucagon
View all literature mentionsThis unknown targets Rat IgG (H+L)
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View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Ghrelin peptides
View all literature mentionsThis polyclonal targets
View all literature mentionsThis polyclonal targets Pancreatic Polypeptide / PPY
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis polyclonal targets Human Chromogranin A
View all literature mentionsThis polyclonal targets Insulin
View all literature mentionsThis monoclonal targets Glucagon
View all literature mentionsThis monoclonal targets Homeobox protein Nkx-6.1; Nkx6.1
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis polyclonal targets Human Chromogranin A
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Homeobox protein Nkx-6.1; Nkx6.1
View all literature mentionsThis monoclonal targets Nkx2.2 transcription factor
View all literature mentionsThis monoclonal targets Ki-67
View all literature mentionsThis unknown targets Guinea Pig IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal targets
View all literature mentionsThis monoclonal targets Ghrelin peptides
View all literature mentionsThis polyclonal targets Pancreatic Polypeptide / PPY
View all literature mentionsThis monoclonal targets Somatostatin
View all literature mentionsThis polyclonal targets Insulin
View all literature mentionsThis monoclonal targets Glucagon
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