Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Cross-compartmental Modulation of Dendritic Signals for Retinal Direction Selectivity.

Neuron | Aug 16, 2017

Compartmentalized signaling in dendritic subdomains is critical for the function of many central neurons. In the retina, individual dendritic sectors of a starburst amacrine cell (SAC) are preferentially activated by different directions of linear motion, indicating limited signal propagation between the sectors. However, the mechanism that regulates this propagation is poorly understood. Here, we find that metabotropic glutamate receptor 2 (mGluR2) signaling, which acts on voltage-gated calcium channels in SACs, selectively restricts cross-sector signal propagation in SACs, but does not affect local dendritic computation within individual sectors. mGluR2 signaling ensures sufficient electrotonic isolation of dendritic sectors to prevent their depolarization during non-preferred motion, yet enables controlled multicompartmental signal integration that enhances responses to preferred motion. Furthermore, mGluR2-mediated dendritic compartmentalization in SACs is important for the functional output of direction-selective ganglion cells (DSGCs). Therefore, our results directly link modulation of dendritic compartmentalization to circuit-level encoding of motion direction in the retina.

Pubmed ID: 28781167 RIS Download

Mesh terms: Action Potentials | Amacrine Cells | Amino Acids | Animals | Animals, Newborn | Cadmium Chloride | Calcium Channel Blockers | Dendrites | Excitatory Amino Acid Antagonists | Female | Inhibitory Postsynaptic Potentials | Male | Mice | Mice, Inbred C57BL | Mice, Transgenic | Motion Perception | Photic Stimulation | Receptors, AMPA | Retina | Signal Transduction | Synapses | Xanthenes | omega-Conotoxin GVIA

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.


pClamp

Commercial patch clamp software from Molecular Devices.

tool

View all literature mentions

MATLAB

A multi-paradigm numerical computing environment and fourth-generation programming language. It allows matrix manipulations, plotting of functions and data, implementation of algorithms, creation of user interfaces, and interfacing with programs written in other languages, including C, C++, Java, Fortran and Python. (Adapted from Wikipedia) The high-level language and interactive environment lets you explore and visualize ideas and collaborate across disciplines including signal and image processing, communications, control systems, and computational finance.

tool

View all literature mentions