The serine protease HtrA is an important factor for regulating stress responses and protein quality control in bacteria. In recent studies, we have demonstrated that the gastric pathogen Helicobacter pylori can secrete HtrA into the extracellular environment, where it cleaves-off the ectodomain of the tumor suppressor and adherens junction protein E-cadherin on gastric epithelial cells.
Pubmed ID: 28770008 RIS Download
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View all literature mentionsCell line Caco-2 is a Cancer cell line with a species of origin Homo sapiens (Human)
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