Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease.

Cell | Jul 13, 2017

The emergence of Zika virus (ZIKV) and its association with congenital malformations has prompted the rapid development of vaccines. Although efficacy with multiple viral vaccine platforms has been established in animals, no study has addressed protection during pregnancy. We tested in mice two vaccine platforms, a lipid nanoparticle-encapsulated modified mRNA vaccine encoding ZIKV prM and E genes and a live-attenuated ZIKV strain encoding an NS1 protein without glycosylation, for their ability to protect against transmission to the fetus. Vaccinated dams challenged with a heterologous ZIKV strain at embryo day 6 (E6) and evaluated at E13 showed markedly diminished levels of viral RNA in maternal, placental, and fetal tissues, which resulted in protection against placental damage and fetal demise. As modified mRNA and live-attenuated vaccine platforms can restrict in utero transmission of ZIKV in mice, their further development in humans to prevent congenital ZIKV syndrome is warranted.

Pubmed ID: 28708997 RIS Download

Mesh terms: Aedes | Animals | Antibodies, Neutralizing | Antibodies, Viral | Blood Cells | Embryo, Mammalian | Female | Fetus | Humans | Lipids | Male | Mice | Mice, Inbred C57BL | Mutation | RNA, Messenger | Specific Pathogen-Free Organisms | Vaccines, Subunit | Viral Nonstructural Proteins | Viral Vaccines | Zika Virus | Zika Virus Infection

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.