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Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.

eLife | Jul 12, 2017

Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor, is selectively expressed in NSCs. Further, Lfng in NSCs and Notch ligands Delta1 and Jagged1, expressed by their progeny, together influence NSC recruitment, cell cycle duration, and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the 'mother' cell to modify its cell cycle status. Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.

Pubmed ID: 28699891 RIS Download

Mesh terms: Animals | Cell Cycle | Cell Proliferation | Gene Expression Regulation | Glycosyltransferases | Hippocampus | Mice | Neural Stem Cells | Receptors, Notch | Signal Transduction

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Associated grants

  • Agency: NIH HHS, Id: S10 OD016167
  • Agency: NICHD NIH HHS, Id: U54 HD083092
  • Agency: NCI NIH HHS, Id: P30 CA125123
  • Agency: NIDCD NIH HHS, Id: R01 DC014832
  • Agency: NIAID NIH HHS, Id: P30 AI036211
  • Agency: NIDCD NIH HHS, Id: R01 DC006185
  • Agency: NCRR NIH HHS, Id: S10 RR024574

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An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

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