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Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.

eLife | 2017

Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (a key modifier of the Notch receptor, is selectively expressed in NSCs. Further, Lfng in NSCs and Notch ligands Delta1 and Jagged1, expressed by their progeny, together influence NSC recruitment, cell cycle duration, and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the 'mother' cell to modify its cell cycle status. Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.

Pubmed ID: 28699891 RIS Download

Mesh terms: Animals | Cell Cycle | Cell Proliferation | Gene Expression Regulation | Glycosyltransferases | Hippocampus | Mice | Neural Stem Cells | Receptors, Notch | Signal Transduction

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GENSAT (tool)

RRID:SCR_002721

Publicly available gene expression atlas of the developing and adult central nervous system in the mouse, using both in situ hybridization and transgenic mouse techniques. It is a collection of pictorial gene expression maps of the brain and spinal cord of the mouse. Using EGFP BAC-transgenics, this project provides the scientific community with tools to catalog, map, and electrophysiologically record from individual cells. The application of Cre recombinase technologies allows for cell-specific gene manipulation. The transgenic mice created by this project are available to the scientific community.

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Jackson Laboratory (tool)

RRID:SCR_004633

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Ki67 antibody (antibody)

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CD31 antibody (antibody)

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Notch 1 (H-131) antibody (antibody)

RRID:AB_650334

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Nestin antibody [2Q178] - Neural Stem Cell Marker (antibody)

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S100 antibody (antibody)

RRID:AB_10013383

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Anti-Polysialic Acid-NCAM, clone 2-2B antibody (antibody)

RRID:AB_11210572

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Rabbit Anti-Notch 1 (Cleaved-Val1754) Polyclonal, Unconjugated antibody (antibody)

RRID:AB_10687460

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Doublecortin (C-18) antibody (antibody)

RRID:AB_2088494

This polyclonal antibody targets Doublecortin (C-18)

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RRID:AB_10015219

This unknown targets BrdU

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Vimentin antibody (antibody)

RRID:AB_2304493

This monoclonal antibody targets VIM

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Anti-NeuN antibody (antibody)

RRID:AB_2298772

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Delta (H-265) antibody (antibody)

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RFP Antibody Pre-adsorbed (antibody)

RRID:AB_2209751

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Jagged1 (H-114) antibody (antibody)

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TBR2 / Eomes antibody - ChIP Grade (antibody)

RRID:AB_778267

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GraphPad Prism (tool)

RRID:SCR_002798

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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