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Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor, is selectively expressed in NSCs. Further, Lfng in NSCs and Notch ligands Delta1 and Jagged1, expressed by their progeny, together influence NSC recruitment, cell cycle duration, and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the 'mother' cell to modify its cell cycle status. Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.
Pubmed ID: 28699891 RIS Download
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View all literature mentionsGene expression data and maps of mouse central nervous system. Gene expression atlas of developing adult central nervous system in mouse, using in situ hybridization and transgenic mouse techniques. Collection of pictorial gene expression maps of brain and spinal cord of mouse. Provides tools to catalog, map, and electrophysiologically record individual cells. Application of Cre recombinase technologies allows for cell-specific gene manipulation. Transgenic mice created by this project are available to scientific community.
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View all literature mentionsThis polyclonal targets Rabbit Notch 1 (Cleaved-Val1754)
View all literature mentionsThis polyclonal targets Notch 1 (H-131)
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsMus musculus with name B6;129S-Jag1tm2Grid/J from IMSR.
View all literature mentionsMus musculus with name B6.129-Dll1tm1Gos/J from IMSR.
View all literature mentionsMus musculus with name B6.129S1-Jag1tm1Grid/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Cp-HIST1H2BB/Venus)47Hadj/J from IMSR.
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name B6;129S1-Lfngtm1Grid/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsMus musculus with name B6;FVB-Tg(Lfng-EGFP)HM340Gsat/Mmucd from MMRRC.
View all literature mentionsThis monoclonal targets Polysialic Acid-NCAM clone 2-2B
View all literature mentionsMus musculus with name B6;129S1-Lfngtm1Grid/J from IMSR.
View all literature mentionsMus musculus with name STOCK Tg(Cp-HIST1H2BB/Venus)47Hadj/J from IMSR.
View all literature mentionsMus musculus with name B6;FVB-Tg(Lfng-EGFP)HM340Gsat/Mmucd from MMRRC.
View all literature mentionsMus musculus with name B6;129S-Jag1tm2Grid/J from IMSR.
View all literature mentionsMus musculus with name B6.129S1-Jag1tm1Grid/J from IMSR.
View all literature mentionsMus musculus with name B6;129S6-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J from IMSR.
View all literature mentionsMus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets sox2
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis polyclonal targets Mouse TBR2 / Eomes
View all literature mentionsThis polyclonal targets S100 isolated from cow brain.
View all literature mentionsThis monoclonal targets Polysialic Acid-NCAM clone 2-2B
View all literature mentionsThis monoclonal targets Nestin antibody [2Q178] - Neural Stem Cell Marker
View all literature mentionsThis polyclonal targets GFAP
View all literature mentionsThis monoclonal targets RAT ANTI BrdU
View all literature mentionsThis monoclonal targets GFAP
View all literature mentionsThis polyclonal targets Doublecortin
View all literature mentionsThis polyclonal targets beta Galactosidase
View all literature mentionsThis polyclonal targets Notch 1 (H-131)
View all literature mentionsThis polyclonal targets RFP
View all literature mentionsMus musculus with name B6.129-Dll1tm1Gos/J from IMSR.
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis polyclonal targets Rabbit Notch 1 (Cleaved-Val1754)
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