Searching across hundreds of databases

Our searching services are busy right now. Your search will reload in five seconds.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.

eLife | 2017

Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (a key modifier of the Notch receptor, is selectively expressed in NSCs. Further, Lfng in NSCs and Notch ligands Delta1 and Jagged1, expressed by their progeny, together influence NSC recruitment, cell cycle duration, and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the 'mother' cell to modify its cell cycle status. Lfng-mediated Notch signaling appears to be a key factor governing NSC quiescence, division, and fate.

Pubmed ID: 28699891 RIS Download

Mesh terms: Animals | Cell Cycle | Cell Proliferation | Gene Expression Regulation | Glycosyltransferases | Hippocampus | Mice | Neural Stem Cells | Receptors, Notch | Signal Transduction

Additional research tools detected in this publication

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

GENSAT (tool)


Publicly available gene expression atlas of the developing and adult central nervous system in the mouse, using both in situ hybridization and transgenic mouse techniques. It is a collection of pictorial gene expression maps of the brain and spinal cord of the mouse. Using EGFP BAC-transgenics, this project provides the scientific community with tools to catalog, map, and electrophysiologically record from individual cells. The application of Cre recombinase technologies allows for cell-specific gene manipulation. The transgenic mice created by this project are available to the scientific community.

View all literature mentions

Jackson Laboratory (tool)


An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

View all literature mentions

Ki67 antibody (antibody)


This monoclonal antibody targets Ki67

View all literature mentions

CD31 antibody (antibody)


This monoclonal antibody targets CD31

View all literature mentions

Notch 1 (H-131) antibody (antibody)


This polyclonal antibody targets Notch 1 (H-131)

View all literature mentions

Anti-HES-5 antibody (antibody)


This polyclonal antibody targets HES-5

View all literature mentions

Nestin antibody [2Q178] - Neural Stem Cell Marker (antibody)


This monoclonal antibody targets Nestin antibody [2Q178] - Neural Stem Cell Marker

View all literature mentions

S100 antibody (antibody)


This polyclonal antibody targets S100 isolated from cow brain.

View all literature mentions

Anti-Polysialic Acid-NCAM, clone 2-2B antibody (antibody)


This monoclonal antibody targets Polysialic Acid-NCAM clone 2-2B

View all literature mentions

Rabbit Anti-Notch 1 (Cleaved-Val1754) Polyclonal, Unconjugated antibody (antibody)


This polyclonal antibody targets Rabbit Notch 1 (Cleaved-Val1754)

View all literature mentions

Doublecortin (C-18) antibody (antibody)


This polyclonal antibody targets Doublecortin (C-18)

View all literature mentions

BrdU antibody (antibody)


This unknown targets BrdU

View all literature mentions

Vimentin antibody (antibody)


This monoclonal antibody targets VIM

View all literature mentions

Anti-NeuN antibody (antibody)


This monoclonal antibody targets NeuN

View all literature mentions

Delta (H-265) antibody (antibody)


This polyclonal antibody targets DLL1

View all literature mentions

RFP Antibody Pre-adsorbed (antibody)


This polyclonal antibody targets RFP Pre-adsorbed

View all literature mentions

Anti-SOX2 antibody (antibody)


This polyclonal antibody targets sox2

View all literature mentions

Jagged1 (H-114) antibody (antibody)


This polyclonal antibody targets JAG1

View all literature mentions

TBR2 / Eomes antibody - ChIP Grade (antibody)


This polyclonal antibody targets TBR2 / Eomes antibody - ChIP Grade

View all literature mentions

GraphPad Prism (tool)


Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

View all literature mentions