Identification of complementary DNAs encoding the human glucocorticoid receptor predicts two protein forms, of 777 (alpha) and 742 (beta) amino acids, which differ at their carboxy termini. The proteins contain a cysteine/lysine/arginine-rich region which may define the DNA-binding domain. Pure radiolabelled glucocorticoid receptor, synthesized in vitro, is immunoreactive and possesses intrinsic steroid-binding activity characteristic of the native glucocorticoid receptor.
Pubmed ID: 2867473 RIS Download
Mesh terms: Amino Acid Sequence | Base Sequence | DNA | Electrophoresis, Polyacrylamide Gel | Gene Expression Regulation | Humans | Macromolecular Substances | Poly A | RNA, Messenger | Receptors, Glucocorticoid
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