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Publication

Cutaneous Leishmaniasis Induces a Transmissible Dysbiotic Skin Microbiota that Promotes Skin Inflammation.

Cell host & microbe | 2017

Skin microbiota can impact allergic and autoimmune responses, wound healing, and anti-microbial defense. We investigated the role of skin microbiota in cutaneous leishmaniasis and found that human patients infected with Leishmania braziliensis develop dysbiotic skin microbiota, characterized by increases in the abundance of Staphylococcus and/or Streptococcus. Mice infected with L. major exhibit similar changes depending upon disease severity. Importantly, this dysbiosis is not limited to the lesion site, but is transmissible to normal skin distant from the infection site and to skin from co-housed naive mice. This observation allowed us to test whether a pre-existing dysbiotic skin microbiota influences disease, and we found that challenging dysbiotic naive mice with L. major or testing for contact hypersensitivity results in exacerbated skin inflammatory responses. These findings demonstrate that a dysbiotic skin microbiota is not only a consequence of tissue stress, but also enhances inflammation, which has implications for many inflammatory cutaneous diseases.

Pubmed ID: 28669672 RIS Download

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Associated grants

Agency: NIAID NIH HHS, United States
Id: F31 AI114227
Agency: NIAMS NIH HHS, United States
Id: R01 AR066663
Agency: NIAID NIH HHS, United States
Id: P50 AI030639
Agency: NIAID NIH HHS, United States
Id: U01 AI088650
Agency: NIAID NIH HHS, United States
Id: R01 AI106842
Agency: NIAMS NIH HHS, United States
Id: T32 AR007465
Agency: NIAMS NIH HHS, United States
Id: R00 AR060873

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