Searching across hundreds of databases
Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated pathways that support transformed CSCs, such as Wnt/β-catenin signaling, are also critical regulators of healthy SCs. Using the ICG-001 and CWP family of small molecules, we reveal Sam68 as a previously unappreciated modulator of Wnt/β-catenin signaling within CSCs. Disruption of CBP-β-catenin interaction via ICG-001/CWP induces the formation of a Sam68-CBP complex in CSCs that alters Wnt signaling toward apoptosis and differentiation induction. Our study identifies Sam68 as a regulator of human CSC vulnerability.
Pubmed ID: 28648376 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This unknown targets Human CD15 CD Antibodies
View all literature mentionsThis monoclonal targets RUNX1 / AML1 antibody [EPR3098]
View all literature mentionsThis monoclonal targets CD45
View all literature mentionsThis monoclonal targets Catenin, beta
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets GAPDH antibody [6C5]
View all literature mentionsThis unknown targets normal rabbit IgG
View all literature mentionsThis unknown targets mouse-IgG-control
View all literature mentionsThis monoclonal targets ChIPAb+ TCF-4
View all literature mentionsThis monoclonal targets TRA-1-60 Antigen
View all literature mentionsThis monoclonal targets SUMO-1 (D-11)
View all literature mentionsThis monoclonal targets Histone H3 (acetyl K18)
View all literature mentionsThis polyclonal targets acetyl-Histone H3 (Lys14)
View all literature mentionsThis monoclonal targets Histone H3 (tri methyl K27) antibody [mAbcam 6002] - ChIP Grade
View all literature mentionsThis polyclonal targets Histone H3 (tri methyl K4)
View all literature mentionsThis monoclonal targets HLA-DR
View all literature mentionsThis monoclonal targets 6X His tag??
View all literature mentionsThis monoclonal targets Human Glycophorin A
View all literature mentionsThis polyclonal targets Human HNF-3 beta / FoxA2
View all literature mentionsThis polyclonal targets c-Myc
View all literature mentionsThis monoclonal targets Human CD44
View all literature mentionsThis monoclonal targets CD41a
View all literature mentionsThis monoclonal targets CD38
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis monoclonal targets CD33
View all literature mentionsThis monoclonal targets CD24
View all literature mentionsThis monoclonal targets Human CD20 (Bp35)
View all literature mentionsThis unknown targets Human CD14 CD Antibodies
View all literature mentionsThis monoclonal targets CD13
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets Active-beta-Catenin
View all literature mentionsCell line SW480 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HT-29 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MCF-7 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line MDA-MB-231 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line OCI-AML-3 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsDatabase of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations and are derived from four sources: Genomic Context, High-throughput experiments, (Conserved) Coexpression, and previous knowledge. STRING quantitatively integrates interaction data from these sources for a large number of organisms, and transfers information between these organisms where applicable. The database currently covers 5''214''234 proteins from 1133 organisms. (2013)
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
