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Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others.

Neuron | Jun 21, 2017

At least 30 types of retinal ganglion cells (RGCs) send distinct messages through the optic nerve to the brain. Available strategies of promoting axon regeneration act on only some of these types. Here we tested the hypothesis that overexpressing developmentally important transcription factors in adult RGCs could reprogram them to a "youthful" growth-competent state and promote regeneration of other types. From a screen of transcription factors, we identified Sox11 as one that could induce substantial axon regeneration. Transcriptome profiling indicated that Sox11 activates genes involved in cytoskeletal remodeling and axon growth. Remarkably, α-RGCs, which preferentially regenerate following treatments such as Pten deletion, were killed by Sox11 overexpression. Thus, Sox11 promotes regeneration of non-α-RGCs, which are refractory to Pten deletion-induced regeneration. We conclude that Sox11 can reprogram adult RGCs to a growth-competent state, suggesting that different growth-promoting interventions promote regeneration in distinct neuronal types.

Pubmed ID: 28641110 RIS Download

Mesh terms: Animals | Axons | Cell Survival | Gene Expression Profiling | Mice | Microscopy, Fluorescence | Nerve Regeneration | Neuronal Outgrowth | Optic Nerve Injuries | PTEN Phosphohydrolase | Regeneration | Retina | Retinal Ganglion Cells | SOXC Transcription Factors

Data used in this publication

None found

Associated grants

  • Agency: NEI NIH HHS, Id: R01 EY021526
  • Agency: NHLBI NIH HHS, Id: T32 HL007901
  • Agency: NINDS NIH HHS, Id: P30 NS062691
  • Agency: NICHD NIH HHS, Id: P30 HD018655
  • Agency: NEI NIH HHS, Id: P30 EY012196
  • Agency: NICHD NIH HHS, Id: U54 HD090255
  • Agency: NEI NIH HHS, Id: R01 EY021342
  • Agency: NEI NIH HHS, Id: R01 EY026939
  • Agency: NINDS NIH HHS, Id: R37 NS029169

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