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The frontotemporal lobar degeneration (FTLD) protein progranulin (PGRN) is essential for proper lysosomal function. PGRN localizes in the lysosomal compartment within the cell. Prosaposin (PSAP), the precursor of lysosomal saposin activators (saposin A, B, C, D), physically interacts with PGRN. Previously, we have shown that PGRN and PSAP facilitate each other's lysosomal trafficking. Here, we report that the interaction between PSAP and PGRN requires the linker region of saposin B and C (BC linker). PSAP protein with the BC linker mutated, fails to interact with PGRN and deliver PGRN to lysosomes in the biosynthetic and endocytic pathways. On the other hand, PGRN interacts with PSAP through multiple granulin motifs. Granulin D and E bind to PSAP with similar affinity as full-length PGRN. Read the Editorial Comment for this article on page 154.
Pubmed ID: 28640985 RIS Download
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View all literature mentionsMus musculus with name B6.129P2-Psaptm1Suz/J from IMSR.
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View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis polyclonal targets Mouse Progranulin Affinity Purified Ab
View all literature mentionsThis monoclonal targets FLAG??
View all literature mentionsThis polyclonal targets Mouse Progranulin Affinity Purified Ab
View all literature mentionsThis monoclonal targets Lamp1
View all literature mentionsMus musculus with name B6.129P2-Psaptm1Suz/J from IMSR.
View all literature mentionsMus musculus with name B6(Cg)-Grntm1.1Aidi/J from IMSR.
View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsThis monoclonal targets Lamp1
View all literature mentionsThis monoclonal targets FLAG??
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