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The ellipsoid body (EB) in the Drosophila brain is a central complex (CX) substructure that harbors circumferentially laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination functions. However, what regulates R axon lamination and how lamination affects R neuron function remain unknown. We show here that the EB is sequentially innervated by small-field and large-field neurons and that early developing EB neurons play an important regulatory role in EB laminae formation. The transmembrane proteins semaphorin-1a (Sema-1a) and plexin A function together to regulate R axon lamination. R neurons recruit both GABA and GABA-A receptors to their axon terminals in the EB, and optogenetic stimulation coupled with electrophysiological recordings show that Sema-1a-dependent R axon lamination is required for preventing the spread of synaptic inhibition between adjacent EB lamina. These results provide direct evidence that EB lamination is critical for local pre-synaptic inhibitory circuit organization.
Pubmed ID: 28632130 RIS Download
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Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
View all literature mentionsImaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.
View all literature mentionsVector graphics software to create digital graphics, illustrations, and typography for several types of media: print, web, interactive, video, and mobile.
View all literature mentionsAn Antibody supplier and subset of ThermoFisher Scientific which provides fluorescence reagents for various experiments and methods.
View all literature mentionsAn antibody supplier which banks and distributes hybridomas and monoclonal antibodies for use in research. The bank includes antibodies against targets such as GFP, transcription factors, stem cells, and human.
View all literature mentionsData analytics software to compute statistical power analyses for many commonly used statistical tests in social and behavioral research. It can also be used to compute effect sizes and to graphically display the results of power analyses.
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsThis monoclonal targets Tyrosine Hydroxylase
View all literature mentionsThis polyclonal targets VGlut
View all literature mentionsThis monoclonal targets choline acetyltransferase
View all literature mentionsThis unknown targets GABA
View all literature mentionsThis monoclonal targets HA- High Affinity (3F10); Rat monoclonal antibody (clone 3F10) conjugated with biotin
View all literature mentionsThis polyclonal targets PlexA
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HM05221}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Mi{Trojan-QF2.2}VGlut[MI04979-TQF2.2]/CyO; P{w[+mC]=QUAS-mCD8-GFP.P}5B from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Mi{Trojan-QF2.0}ChAT[MI04508-TQF2.0] CG7715[MI04508-TQF2.0-X]/TM6B, Tb[1] from BDSC.
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{Trojan-QF2.2}Gad1[MI09277-TQF2.2]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{GFP[E.3xP3]=ET1}PlexA[MB09499]/In(4)ci[D], ci[D] pan[ciD] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mC]=lacW}Sema1a[k13702]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS01307}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; PBac{y[+mDint2] w[+mC]=UAS-Sema1a.mEC-5xmyc}VK00033 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; PBac{y[+mDint2] w[+mC]=UAS-Sema1a.J}VK00033 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=13XLexAop2-IVS-CsChrimson.mVenus}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=8XLexAop2-IVS-GAL80-WPRE}su(Hw)attP1 from BDSC.
View all literature mentionsDrosophila melanogaster with name P{w[+mC]=UAS-Dcr-2.D}1, w[1118]; betaTub60D[Pin-1]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}10; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-nSyb-spGFP1-10}2, P{w[+mC]=lexAop-CD4-spGFP11}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}22, y[1] w[*]; P{w[+mW.hs]=FRT(w[hs])}G13; P{w[+mC]=GMR-CD4-spGFP11}3, P{w[+mC]=UAS-CD4-spGFP1-10}3 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-DenMark}2, P{w[+mC]=UAS-syt.eGFP}2; In(3L)D, mirr[SaiD1] D[1]/TM6C, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; PBac{y[+mDint2] w[+mC]=13XLexAop2-6XmCherry-HA}VK00018/CyO, P{Wee-P.ph0}Bacc[Wee-P20]; Dr[1]/TM6C, Sb[1] Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; betaTub60D[Pin-Yt]/CyO; P{w[+mC]=UAS-mCD8::GFP.L}LL6 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HM05221}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; betaTub60D[Pin-Yt]/CyO; P{w[+mC]=UAS-mCD8::GFP.L}LL6 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=UAS-DenMark}2, P{w[+mC]=UAS-syt.eGFP}2; In(3L)D, mirr[SaiD1] D[1]/TM6C, Sb[1] from BDSC.
View all literature mentionsThis polyclonal targets VGlut
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HM05221}attP2 from BDSC.
View all literature mentionsThis monoclonal targets Tyrosine Hydroxylase
View all literature mentionsThis monoclonal targets choline acetyltransferase
View all literature mentionsThis unknown targets GABA
View all literature mentionsThis monoclonal targets HA- High Affinity (3F10); Rat monoclonal antibody (clone 3F10) conjugated with biotin
View all literature mentionsThis polyclonal targets PlexA
View all literature mentionsThis polyclonal targets DsRed
View all literature mentionsThis monoclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsDrosophila melanogaster with name w[*]; Mi{Trojan-QF2.2}VGlut[MI04979-TQF2.2]/CyO; P{w[+mC]=QUAS-mCD8-GFP.P}5B from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; Mi{Trojan-QF2.0}ChAT[MI04508-TQF2.0] CG7715[MI04508-TQF2.0-X]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{Trojan-QF2.2}Gad1[MI09277-TQF2.2]/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; Mi{GFP[E.3xP3]=ET1}PlexA[MB09499]/In(4)ci[D], ci[D] pan[ciD] from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; P{w[+mC]=lacW}Sema1a[k13702]/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.HMS01307}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; PBac{y[+mDint2] w[+mC]=UAS-Sema1a.mEC-5xmyc}VK00033 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; PBac{y[+mDint2] w[+mC]=UAS-Sema1a.J}VK00033 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; PBac{y[+mDint2] w[+mC]=13XLexAop2-6XmCherry-HA}VK00018/CyO, P{Wee-P.ph0}Bacc[Wee-P20]; Dr[1]/TM6C, Sb[1] Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=13XLexAop2-IVS-CsChrimson.mVenus}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{y[+t7.7] w[+mC]=8XLexAop2-IVS-GAL80-WPRE}su(Hw)attP1 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=tubP-GAL80[ts]}10; TM2/TM6B, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=UAS-nSyb-spGFP1-10}2, P{w[+mC]=lexAop-CD4-spGFP11}2/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}22, y[1] w[*]; P{w[+mW.hs]=FRT(w[hs])}G13; P{w[+mC]=GMR-CD4-spGFP11}3, P{w[+mC]=UAS-CD4-spGFP1-10}3 from BDSC.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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