Searching across hundreds of databases
Host defense requires the specification of CD4+ helper T (Th) cells into distinct fates, including Th1 cells that preferentially produce interferon-γ (IFN-γ). IFN-γ, a member of a large family of anti-pathogenic and anti-tumor IFNs, induces T-bet, a lineage-defining transcription factor for Th1 cells, which in turn supports IFN-γ production in a feed-forward manner. Herein, we show that a cell-intrinsic role of T-bet influences how T cells perceive their secreted product in the environment. In the absence of T-bet, IFN-γ aberrantly induced a type I IFN transcriptomic program. T-bet preferentially repressed genes and pathways ordinarily activated by type I IFNs to ensure that its transcriptional response did not evoke an aberrant amplification of type I IFN signaling circuitry, otherwise triggered by its own product. Thus, in addition to promoting Th1 effector commitment, T-bet acts as a repressor in differentiated Th1 cells to prevent abberant autocrine type I IFN and downstream signaling.
Pubmed ID: 28623086 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Software performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsSoftware performing alignment of high-throughput RNA-seq data. Aligns RNA-seq reads to reference genome using uncompressed suffix arrays.
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis monoclonal targets IFNAR1
View all literature mentionsThis monoclonal targets IRF7
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets NK1.1
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets CD62L (L-Selectin)
View all literature mentionsThis monoclonal targets CD45.2
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD25
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets IL-4
View all literature mentionsThis monoclonal targets IFNγ
View all literature mentionsThis monoclonal targets CD28
View all literature mentionsThis monoclonal targets CD3e
View all literature mentionsThis polyclonal targets Human Signal Transducer and Activator Of Transcription 2 (STAT2)
View all literature mentionsThis polyclonal targets STAT2
View all literature mentionsThis polyclonal targets H3K4me1
View all literature mentionsThis polyclonal targets H3K27ac
View all literature mentionsThis polyclonal targets STAT2 antibody
View all literature mentionsThis polyclonal targets STAT1
View all literature mentionsMus musculus with name B6.129S6-Tbx21tm1Glm/J from IMSR.
View all literature mentionsMus musculus with name C.B6(Cg)-Rag2tm1.1Cgn/J from IMSR.
View all literature mentions
Mus musculus with name B6.SJL-Ptprca Pepc
Java software for studying protein-DNA interaction using ChIP-seq / ChIP-exo data. It links binding event discovery and motif discovery with positional priors in the context of a generative probabilistic model of ChIP data and genome sequence, resolves ChIP data into explanatory motifs and binding events at unsurpassed spatial resolution. GEM reciprocally improves motif discovery using binding event locations, and binding event predictions using discovered motifs.
View all literature mentionsSoftware Python package for identifying transcript factor binding sites. Used to evaluate significance of enriched ChIP regions. Improves spatial resolution of binding sites through combining information of both sequencing tag position and orientation. Can be used for ChIP-Seq data alone, or with control sample with increase of specificity.
View all literature mentionsSoftware ultrafast memory efficient tool for aligning sequencing reads. Bowtie is short read aligner.
View all literature mentionsA high-performance visualization tool for interactive exploration of large, integrated genomic datasets.
View all literature mentionsA powerful toolset for genome arithmetic allowing one to address common genomics tasks such as finding feature overlaps and computing coverage. Bedtools allows one to intersect, merge, count, complement, and shuffle genomic intervals from multiple files in widely-used genomic file formats such as BAM, BED, GFF/GTF, VCF. While each individual tool is designed to do a relatively simple task (e.g., intersect two interval files), quite sophisticated analyses can be conducted by combining multiple bedtools operations on the UNIX command line.
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis monoclonal targets IFNAR1
View all literature mentionsThis monoclonal targets IRF7
View all literature mentionsThis isotype control targets Not Applicable
View all literature mentionsThis monoclonal targets IFNAR1
View all literature mentionsThis monoclonal targets IRF7
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
