Searching across hundreds of databases
CD4 T cells are critical for protective immunity against Mycobacterium tuberculosis (Mtb), the cause of tuberculosis (TB). Yet to date, TB vaccine candidates that boost antigen-specific CD4 T cells have conferred little or no protection. Here we examined CD4 T cell responses to two leading TB vaccine antigens, ESAT-6 and Ag85B, in Mtb-infected mice and in vaccinated humans with and without underlying Mtb infection. In both species, Mtb infection drove ESAT-6-specific T cells to be more differentiated than Ag85B-specific T cells. The ability of each T cell population to control Mtb in the lungs of mice was restricted for opposite reasons: Ag85B-specific T cells were limited by reduced antigen expression during persistent infection, whereas ESAT-6-specific T cells became functionally exhausted due to chronic antigenic stimulation. Our findings suggest that different vaccination strategies will be required to optimize protection mediated by T cells recognizing antigens expressed at distinct stages of Mtb infection.
Pubmed ID: 28618268 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
This monoclonal targets CD8
View all literature mentionsThis monoclonal targets TNF-alpha
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets KLRG1
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis monoclonal targets IFN gamma
View all literature mentionsThis monoclonal targets F4/80 Antigen
View all literature mentionsThis monoclonal targets CD279
View all literature mentionsThis monoclonal targets CD197 (CCR7)
View all literature mentionsThis monoclonal targets CD127
View all literature mentionsThis monoclonal targets CD62L
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD44
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD3
View all literature mentionsThis monoclonal targets CD14
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets Human CD45RA
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis unknown targets mouse Ig k
View all literature mentionsThis monoclonal targets CD45RA
View all literature mentionsThis monoclonal targets Human CD197
View all literature mentionsThis monoclonal targets IL-2
View all literature mentionsThis monoclonal targets TNF alpha
View all literature mentionsThis monoclonal targets IFN-γ
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD49d
View all literature mentionsThis monoclonal targets CD28
View all literature mentionsSoftware environment and programming language for statistical computing and graphics. R is integrated suite of software facilities for data manipulation, calculation and graphical display. Can be extended via packages. Some packages are supplied with the R distribution and more are available through CRAN family.It compiles and runs on wide variety of UNIX platforms, Windows and MacOS.
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsSoftware for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
scicrunch.org
