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Nanospan, an alternatively spliced isoform of sarcospan, localizes to the sarcoplasmic reticulum in skeletal muscle and is absent in limb girdle muscular dystrophy 2F.

Skeletal muscle | 2017

Sarcospan (SSPN) is a transmembrane protein that interacts with the sarcoglycans (SGs) to form a tight subcomplex within the dystrophin-glycoprotein complex that spans the sarcolemma and interacts with laminin in the extracellular matrix. Overexpression of SSPN ameliorates Duchenne muscular dystrophy in murine models.

Pubmed ID: 28587652 RIS Download

Research resources used in this publication

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Associated grants

  • Agency: NIAMS NIH HHS, United States
    Id: R01 AR048179
  • Agency: NIGMS NIH HHS, United States
    Id: T32 GM065823
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR000124
  • Agency: NIAMS NIH HHS, United States
    Id: P30 AR057230
  • Agency: NIAMS NIH HHS, United States
    Id: R01 AR063710
  • Agency: NIAMS NIH HHS, United States
    Id: R21 AR067422
  • Agency: NIAMS NIH HHS, United States
    Id: R01 AR041802
  • Agency: Howard Hughes Medical Institute, United States
  • Agency: NIAMS NIH HHS, United States
    Id: T32 AR065972

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AxioVision Imaging System (tool)

RRID:SCR_002677

Digital image processing system where microscope settings and processing steps may be adjusted in single user interface. Can acquire images from variety of cameras. Includes software package for capturing, archiving and preparing images for publication. Allows users to visualize and present images in several dimensions. Functionality of imaging toolbox expands constantly with wide range of different modules that are tailored to specific applications or microscope accessories. This resource is duplicated by SCR_018376

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Jackson Laboratory (tool)

RRID:SCR_004633

An independent, nonprofit organization focused on mammalian genetics research to advance human health. Their mission is to discover the genetic basis for preventing, treating, and curing human disease, and to enable research for the global biomedical community. Jackson Laboratory breeds and manages colonies of mice as resources for other research institutions and laboratories, along with providing software and techniques. Jackson Lab also conducts genetic research and provides educational material for various educational levels.

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B6.129-Sgcdtm1Mcn/J (tool)

RRID:IMSR_JAX:004582

Mus musculus with name B6.129-Sgcdtm1Mcn/J from IMSR.

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C57BL/10ScSn-Dmdmdx/J (tool)

RRID:IMSR_JAX:001801

Mus musculus with name C57BL/10ScSn-Dmdmdx/J from IMSR.

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