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Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development.

Developmental cell | May 22, 2017

The kidney contains the functional units, the nephrons, surrounded by the renal interstitium. Previously we discovered that, once Six2-expressing nephron progenitor cells and Foxd1-expressing renal interstitial progenitor cells form at the onset of kidney development, descendant cells from these populations contribute exclusively to the main body of nephrons and renal interstitial tissues, respectively, indicating a lineage boundary between the nephron and renal interstitial compartments. Currently it is unclear how lineages are regulated during kidney organogenesis. We demonstrate that nephron progenitor cells lacking Pax2 fail to differentiate into nephron cells but can switch fates into renal interstitium-like cell types. These data suggest that Pax2 function maintains nephron progenitor cells by repressing a renal interstitial cell program. Thus, the lineage boundary between the nephron and renal interstitial compartments is maintained by the Pax2 activity in nephron progenitor cells during kidney organogenesis.

Pubmed ID: 28535371 RIS Download

Mesh terms: Alleles | Animals | Body Patterning | Cell Transdifferentiation | Forkhead Transcription Factors | Gene Expression Profiling | Homeodomain Proteins | Mesoderm | Mice, Inbred C57BL | Nephrons | Organogenesis | PAX2 Transcription Factor | Sequence Analysis, RNA | Single-Cell Analysis | Stem Cells | Stromal Cells | Transcription Factors

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Associated grants

  • Agency: NIDDK NIH HHS, Id: R01 DK054364
  • Agency: NIDDK NIH HHS, Id: R01 DK094933
  • Agency: NIH HHS, Id: R21 OD021437
  • Agency: NIDDK NIH HHS, Id: R37 DK054364

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GenitoUrinary Development Molecular Anatomy Project

International consortium providing a molecular atlas of gene expression for the developing organs of the GenitoUrinary (GU) tract; a high resolution molecular anatomy highlighting development of the GU system; mouse strains to facilitate developmental and functional studies within the GU system; experimental protocols and standard specifications; tutorials describing GU organogenesis and primary data via the database. The data are from large-scale in situ hybridization screens (wholemount and section) and microarray gene expression data of microdissected, laser-captured and FACS-sorted components of the developing mouse genitourinary (GU) system. These expression data are annotated using a high-resolution anatomy ontology specific to the developing murine GU system.


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