Endocannabinoids (ECBs) depress transmitter release at sites throughout the brain. Here, we describe another form of ECB signaling that triggers a novel form of long-term potentiation (LTP) localized to the lateral perforant path (LPP) which conveys semantic information from cortex to hippocampus. Two cannabinoid CB1 receptor (CB1R) signaling cascades were identified in hippocampus. The first is pregnenolone sensitive, targets vesicular protein Munc18-1 and depresses transmitter release; this cascade is engaged by CB1Rs in Schaffer-Commissural afferents to CA1 but not in the LPP, and it does not contribute to LTP. The second cascade is pregnenolone insensitive and LPP specific; it entails co-operative CB1R/β1-integrin signaling to effect synaptic potentiation via stable enhancement of transmitter release. The latter cascade is engaged during LPP-dependent learning. These results link atypical ECB signaling to the encoding of a fundamental component of episodic memory and suggest a novel route whereby endogenous and exogenous cannabinoids affect cognition.
Pubmed ID: 28520937 RIS Download
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View all literature mentionsThis unknown targets Phospho-PYK2 (Tyr402)
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View all literature mentionsThis monoclonal targets Integrin beta1 clone P4C10 azide free
View all literature mentionsThis monoclonal targets Mouse Integrin alpha V
View all literature mentionsThis unknown targets Phospho-PYK2 (Tyr402)
View all literature mentionsThis monoclonal targets Integrin beta1 clone P4C10 azide free
View all literature mentionsThis polyclonal targets Phospho-FAK (Tyr397)
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View all literature mentionsThis polyclonal targets ROCK2 (phospho Ser1366)
View all literature mentions