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Cooperating Commensals Restore Colonization Resistance to Vancomycin-Resistant Enterococcus faecium.

Cell host & microbe | May 10, 2017

Antibiotic-mediated microbiota destruction and the consequent loss of colonization resistance can result in intestinal domination with vancomycin-resistant Enterococcus (VRE), leading to bloodstream infection in hospitalized patients. Clearance of VRE remains a challenging goal that, if achieved, would reduce systemic VRE infections and patient-to-patient transmission. Although obligate anaerobic commensal bacteria have been associated with colonization resistance to VRE, the specific bacterial species involved remain undefined. Herein, we demonstrate that a precisely defined consortium of commensal bacteria containing the Clostridium cluster XIVa species Blautia producta and Clostridium bolteae restores colonization resistance against VRE and clears VRE from the intestines of mice. While C. bolteae did not directly mediate VRE clearance, it enabled intestinal colonization with B. producta, which directly inhibited VRE growth. These findings suggest that therapeutic or prophylactic administration of defined bacterial consortia to individuals with compromised microbiota composition may reduce inter-patient transmission and intra-patient dissemination of highly antibiotic-resistant pathogens.

Pubmed ID: 28494240 RIS Download

Mesh terms: Ampicillin | Animals | Anti-Bacterial Agents | Bacteria | Bacterial Physiological Phenomena | Clostridium | Colony Count, Microbial | DNA, Bacterial | Drug Resistance, Bacterial | Enterococcus faecium | Feces | Female | Gram-Positive Bacterial Infections | Intestines | Mice | Mice, Inbred C57BL | Microbiota | RNA, Ribosomal, 16S | Symbiosis | Vancomycin | Vancomycin-Resistant Enterococci

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