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Noise induced hearing loss (NIHL) is a disease that affects millions of Americans. Identifying genetic pathways that influence recovery from noise exposure is an important step forward in understanding NIHL. The transcription factor Foxo3 integrates the cellular response to oxidative stress and plays a role in extending lifespan in many organisms, including humans. Here we show that Foxo3 is required for auditory function after noise exposure in a mouse model system, measured by ABR. Absent Foxo3, outer hair cells are lost throughout the middle and higher frequencies. SEM reveals persistent damage to some surviving outer hair cell stereocilia. However, DPOAE analysis reveals that some function is preserved in low frequency outer hair cells, despite concomitant profound hearing loss. Inner hair cells, auditory synapses and spiral ganglion neurons are all present after noise exposure in the Foxo3KO/KO fourteen days post noise (DPN). We also report anti-Foxo3 immunofluorescence in adult human outer hair cells. Taken together, these data implicate Foxo3 and its transcriptional targets in outer hair cell survival after noise damage. An additional role for Foxo3 in preserving hearing is likely, as low frequency auditory function is absent in noise exposed Foxo3KO/KOs even though all cells and structures are present.
Pubmed ID: 28432353 RIS Download
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Software tool for visualizing, manipulating, and understanding data from tomography, microscopy, MRI and other imaging processes.Used to import and export options, to processes 3D image filtering and DTI based fiber tracking to visualization, volume and surface rendering, author tools for virtual reality navigation, video generation, and more.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE, documented on February 1st, 2022. Software application for genetic analysis of classical biometric traits like blood pressure or height that are caused by a combination of polygenic inheritance and complex environmental forces. (entry from Genetic Analysis Software)
View all literature mentionsSoftware for image processing, analysis, and editing. The software includes features such as touch capabilities, a customizable toolbar, 2D and 3D image merging, and Cloud access and options.
View all literature mentionsSoftware tool for visualizing, manipulating, and understanding data from tomography, microscopy, MRI and other imaging processes.Used to import and export options, to processes 3D image filtering and DTI based fiber tracking to visualization, volume and surface rendering, author tools for virtual reality navigation, video generation, and more.
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View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 2a Specific
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 2a Specific
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 2a Specific
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 1 Specific
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 1 Specific
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 1 Specific
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View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 1 Specific
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 1 Specific
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 2a Specific
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsThis polyclonal targets OCM, OCM2
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 1 Specific
View all literature mentionsThis unknown targets Mouse IgG (H+L)
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View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets Glutamate Receptor 2 (GluR2), aa175-430
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View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsThis unknown targets Goat IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG, Fc? Subclass 2a Specific
View all literature mentionsThis polyclonal targets IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis monoclonal targets Glutamate Receptor 2 (GluR2), aa175-430
View all literature mentionsThis monoclonal targets Glutamate Receptor 2 (GluR2), aa175-430
View all literature mentionsThis monoclonal targets CtBP2
View all literature mentionsThis monoclonal targets Glutamate Receptor 2 (GluR2), aa175-430
View all literature mentionsThis monoclonal targets CtBP2
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets Glutamate Receptor 2 (GluR2), aa175-430
View all literature mentionsThis monoclonal targets Glutamate Receptor 2 (GluR2), aa175-430
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis monoclonal targets CtBP2
View all literature mentionsThis polyclonal targets Myosin-VI
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View all literature mentionsThis unknown targets FOXO3A
View all literature mentionsThis unknown targets FOXO3A
View all literature mentionsThis polyclonal targets Myosin-VI
View all literature mentionsThis unknown targets FOXO3A
View all literature mentionsThis unknown targets FOXO3A
View all literature mentionsThis polyclonal targets OCM, OCM2
View all literature mentionsThis unknown targets FOXO3A
View all literature mentionsThis polyclonal targets OCM, OCM2
View all literature mentionsThis polyclonal targets OCM, OCM2
View all literature mentionsThis polyclonal targets OCM, OCM2
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsThis monoclonal targets CtBP2
View all literature mentionsThis polyclonal targets OCM, OCM2
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsThis monoclonal targets CtBP2
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsThis monoclonal targets TUBB2A
View all literature mentionsThis polyclonal targets Myosin-VI
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
View all literature mentionsMus musculus with name FVB/NJ from IMSR.
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View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis unknown targets Mouse IgG (H+L)
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