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The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. An unusually low rate of vesicular transport (transcytosis) has been identified as one of the two unique properties of CNS endothelial cells, relative to peripheral endothelial cells, that maintain the restrictive quality of the BBB. However, it is not known how this low rate of transcytosis is achieved. Here we provide a mechanism whereby the regulation of CNS endothelial cell lipid composition specifically inhibits the caveolae-mediated transcytotic route readily used in the periphery. An unbiased lipidomic analysis reveals significant differences in endothelial cell lipid signatures from the CNS and periphery, which underlie a suppression of caveolae vesicle formation and trafficking in brain endothelial cells. Furthermore, lipids transported by Mfsd2a establish a unique lipid environment that inhibits caveolae vesicle formation in CNS endothelial cells to suppress transcytosis and ensure BBB integrity.
Pubmed ID: 28416077 RIS Download
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View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsCell line bEnd.3 is a Transformed cell line with a species of origin Mus musculus (Mouse)
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View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis monoclonal targets α-tubulin
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis polyclonal targets
View all literature mentionsThis recombinant monoclonal targets PDGFRB
View all literature mentionsThis polyclonal targets Human VE Cadherin
View all literature mentionsThis monoclonal targets Caveolin-1
View all literature mentionsThis monoclonal targets 129/Sv mouse-derived endothelioma cell line tEnd.1
View all literature mentionsThis monoclonal targets Claudin 5
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View all literature mentionsThis monoclonal targets α-tubulin
View all literature mentionsThis monoclonal targets β-Actin
View all literature mentionsThis recombinant monoclonal targets PDGFRB
View all literature mentionsThis polyclonal targets
View all literature mentionsThis polyclonal targets Human VE Cadherin
View all literature mentionsThis monoclonal targets Caveolin-1
View all literature mentionsThis monoclonal targets Claudin 5
View all literature mentionsThis monoclonal targets 129/Sv mouse-derived endothelioma cell line tEnd.1
View all literature mentionsMus musculus with name STOCK Cav1tm1Mls/J from IMSR.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
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