Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several obstacles, including identification of suitable targets and optimal warheads. Here, we demonstrate that the cell-surface protein CD276/B7-H3 is broadly overexpressed by multiple tumor types on both cancer cells and tumor-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target. In preclinical studies CD276 ADCs armed with a conventional MMAE warhead destroyed CD276-positive cancer cells, but were ineffective against tumor vasculature. In contrast, pyrrolobenzodiazepine-conjugated CD276 ADCs killed both cancer cells and tumor vasculature, eradicating large established tumors and metastases, and improving long-term overall survival. CD276-targeted dual-compartment ablation could aid in the development of highly selective broad-acting anti-cancer therapies.
Pubmed ID: 28399408 RIS Download
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This monoclonal targets IgG
View all literature mentionsThis monoclonal targets CD276
View all literature mentionsThis monoclonal targets P-glycoprotein 1
View all literature mentionsThis unknown targets Human myeloma serum
View all literature mentionsThis unknown targets Goat IgG, F'2 Fragment Specific
View all literature mentionsThis unknown targets IgG
View all literature mentionsThis unknown targets IgG
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View all literature mentionsThis unknown targets Biotin
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis unknown targets Human IgG (H+L)
View all literature mentionsThis unknown targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal targets Mouse IgG (H+L)
View all literature mentionsThis unknown targets Biotin
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis monoclonal targets CD31
View all literature mentionsThis polyclonal targets Fluorescein (FITC) / Oregon Green
View all literature mentionsThis monoclonal targets Mouse pan ECA
View all literature mentionsThis monoclonal targets KRT7
View all literature mentionsThis monoclonal targets Mouse PECAM-1
View all literature mentionsThis polyclonal targets Human B7-H3 Affinity Purified Ab
View all literature mentionsThis polyclonal targets Human/Mouse Desmin Affinity Purified Ab
View all literature mentionsThis monoclonal targets CD8a
View all literature mentionsThis monoclonal targets CD11b
View all literature mentionsThis monoclonal targets CD11c
View all literature mentionsThis monoclonal targets CD19
View all literature mentionsThis monoclonal targets Ly-6G
View all literature mentionsThis monoclonal targets Ly-6C
View all literature mentionsThis monoclonal targets CD4
View all literature mentionsThis monoclonal targets CD45R (B220)
View all literature mentionsThis monoclonal targets Ly-6G/Ly-6C
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View all literature mentionsThis monoclonal targets CD31
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View all literature mentionsThis polyclonal targets Von Willebrand Factor
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View all literature mentionsCell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsMus musculus with name CB17/Icr-Prkdcscid/IcrCr from IMSR.
View all literature mentionsMus musculus with name C57BL/6NCrl from IMSR.
View all literature mentionsMus musculus with name Crl:NU(NCr)-Foxn1nu from IMSR.
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View all literature mentionsCell line NCTC clone 929 is a Spontaneously immortalized cell line with a species of origin Mus musculus
View all literature mentionsCell line Py230 is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsCell line bEnd.3 is a Transformed cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsCell line SW620 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line DLD-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HEK293 is a Transformed cell line with a species of origin Homo sapiens (Human)
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