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Publication

Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn.

Neuron | 2017

Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels essential to these activities remain to be identified. Because deficiency of sodium leak channel, non-selective (Nalcn) causes lethal apnea in humans and mice, we investigated Nalcn function in these neuronal groups. We found that one-third of mice lacking Nalcn in excitatory preBötC neurons died soon after birth; surviving mice developed apneas in adulthood. Interestingly, in both preBötC and RTN neurons, the Nalcn current influences the resting membrane potential, contributes to maintenance of stable network activity, and mediates modulatory responses to the neuropeptide substance P. These findings reveal Nalcn's specific role in both rhythmic stability and responsiveness to neuropeptides within the respiratory network.

Pubmed ID: 28392070 RIS Download

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Associated grants

Agency: NINDS NIH HHS, United States
Id: R01 NS100893
Agency: NINDS NIH HHS, United States
Id: R01 NS055293
Agency: NICHD NIH HHS, United States
Id: U54 HD083092
Agency: NCI NIH HHS, United States
Id: P30 CA125123
Agency: NIAID NIH HHS, United States
Id: P30 AI036211
Agency: NCRR NIH HHS, United States
Id: S10 RR024574
Agency: Howard Hughes Medical Institute, United States
Agency: NIGMS NIH HHS, United States
Id: T32 GM008307
Agency: NINDS NIH HHS, United States
Id: R01 NS074257

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