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Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia.

Neuron | Apr 5, 2017

The basal ganglia (BG) integrate inputs from diverse sensorimotor, limbic, and associative regions to guide action-selection and goal-directed behaviors. The entopeduncular nucleus (EP) is a major BG output nucleus and has been suggested to channel signals from distinct BG nuclei to target regions involved in diverse functions. Here we use single-cell transcriptional and molecular analyses to demonstrate that the EP contains at least three classes of projection neurons-glutamate/GABA co-releasing somatostatin neurons, glutamatergic parvalbumin neurons, and GABAergic parvalbumin neurons. These classes comprise functionally and anatomically distinct output pathways that differentially affect EP target regions, such as the lateral habenula (LHb) and thalamus. Furthermore, LHb- and thalamic-projecting EP neurons are differentially innervated by subclasses of striatal and pallidal neurons. Therefore, we identify previously unknown subdivisions within the EP and reveal the existence of cascading, molecularly distinct projections through striatum and globus pallidus to EP targets within epithalamus and thalamus.

Pubmed ID: 28384468 RIS Download

Mesh terms: Animals | Basal Ganglia | Entopeduncular Nucleus | GABAergic Neurons | Gene Expression Profiling | Globus Pallidus | Glutamic Acid | Habenula | Humans | In Situ Hybridization, Fluorescence | Limbic System | Mice | Neostriatum | Neurons | Parvalbumins | Sensorimotor Cortex | Single-Cell Analysis | Somatostatin | Thalamus

Data used in this publication

None found

Associated grants

  • Agency: NINDS NIH HHS, Id: R37 NS046579
  • Agency: NINDS NIH HHS, Id: P30 NS072030
  • Agency: Howard Hughes Medical Institute, Id: R01 NS046579
  • Agency: NINDS NIH HHS, Id: T32 NS007484
  • Agency: NINDS NIH HHS, Id:

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