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Collective migration of epithelial cells underlies diverse tissue-remodeling events, but the mechanisms that coordinate individual cell migratory behaviors for collective movement are largely unknown. Studying the Drosophila follicular epithelium, we show that the cadherin Fat2 and the receptor tyrosine phosphatase Lar function in a planar signaling system that coordinates leading and trailing edge dynamics between neighboring cells. Fat2 signals from each cell's trailing edge to induce leading edge protrusions in the cell behind, in part by stabilizing Lar's localization in these cells. Conversely, Lar signals from each cell's leading edge to stimulate trailing edge retraction in the cell ahead. Fat2/Lar signaling is similar to planar cell polarity signaling in terms of sub-cellular protein localization; however, Fat2/Lar signaling mediates short-range communication between neighboring cells instead of transmitting long-range information across a tissue. This work defines a key mechanism promoting epithelial migration and establishes a different paradigm for planar cell-cell signaling.
Pubmed ID: 28292425 RIS Download
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This polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets cadherin, DN- (extracellular domain)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal targets Green Fluorescent Protein (GFP)
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets acetylated alpha Tubulin
View all literature mentionsThis monoclonal targets Discs large (Drosophila)
View all literature mentionsThis monoclonal targets DLAR
View all literature mentionsDrosophila melanogaster with name w[1118]; PBac{802.P.SVS-2}msn[CPTI003908] from DGGR.
View all literature mentionsDrosophila melanogaster with name y[*] w[*]; P{GawB}tj[NP1624] / CyO, P{UAS-lacZ.UW14}UW14 from DGGR.
View all literature mentionsDrosophila melanogaster with name y[1] w[67c23]; MKRS, P{ry[+t7.2]=hsFLP}86E/TM6B, P{w[+mC]=Crew}DH2, Tb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=hsFLP}22, w[*] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=GAL4-Act5C(FRT.CD2).P}S, P{w[+mC]=UAS-RFP.W}3/TM3, Sb[1] from BDSC.
View all literature mentionsDrosophila melanogaster with name w[*]; P{w[+mC]=Ubi-GFP.D}61EF P{ry[+t7.2]=neoFRT}80B from BDSC.
View all literature mentionsDiscontinued
View all literature mentionsDrosophila melanogaster with name y[1] w[1118]; P{w[+mC]=Ubi-mRFP.nls}2L P{ry[+t7.2]=neoFRT}40A/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118]; P{w[+mC]=Ubi-GFP(S65T)nls}2L P{ry[+t7.2]=neoFRT}40A/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name P{ry[+t7.2]=neoFRT}40A; P{w[+mW.hs]=GawB}T155 P{w[+mC]=UAS-FLP.D}JD2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] w[*]; P{w[+mW.hs]=en2.4-GAL4}e22c P{w[+mC]=UAS-FLP.D}JD1/CyO from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] sc[*] v[1] sev[21]; P{y[+t7.7] v[+t1.8]=TRiP.GL00367}attP2 from BDSC.
View all literature mentionsDrosophila melanogaster with name y[1] v[1]; P{y[+t7.7] v[+t1.8]=TRiP.HMS02136}attP40 from BDSC.
View all literature mentionsDrosophila melanogaster with name w[1118] from BDSC.
View all literature mentionsTHIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 5,2022.Tool that predicts interactions between transcription factors and their regulated genes from binding motifs. Understanding vertebrate development requires unraveling the cis-regulatory architecture of gene regulation. PRISM provides accurate genome-wide computational predictions of transcription factor binding sites for the human and mouse genomes, and integrates the predictions with GREAT to provide functional biological context. Together, accurate computational binding site prediction and GREAT produce for each transcription factor: 1. putative binding sites, 2. putative target genes, 3. putative biological roles of the transcription factor, and 4. putative cis-regulatory elements through which the factor regulates each target in each functional role.
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View all literature mentionsOpen source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsThis unknown targets Rat IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
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