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Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice.

During pregnancy and lactation, subcutaneous white adipocytes in the mouse mammary gland transdifferentiate reversibly to milk-secreting epithelial cells. In this study, we demonstrate by transmission electron microscopy that in the post-lactating mammary gland interscapular multilocular adipocytes found close to the mammary alveoli contain milk protein granules. Use of the Cre-loxP recombination system allowed showing that the involuting mammary gland of whey acidic protein-Cre/R26R mice, whose secretory alveolar cells express the lacZ gene during pregnancy, contains some X-Gal-stained and uncoupling protein 1-positive interscapular multilocular adipocytes. These data suggest that during mammary gland involution some milk-secreting epithelial cells in the anterior subcutaneous depot may transdifferentiate to brown adipocytes, highlighting a hitherto unappreciated feature of mouse adipose organ plasticity.

Pubmed ID: 28191637 RIS Download

Mesh terms: Adipocytes, Brown | Animals | Cell Lineage | Cell Plasticity | Cell Transdifferentiation | Epithelial Cells | Female | Genotype | Integrases | Lactation | Mammary Glands, Animal | Mice, Inbred C57BL | Mice, Transgenic | Microscopy, Electron, Transmission | Milk Proteins | Phenotype | Pregnancy | RNA, Untranslated | Uncoupling Protein 1 | Weaning | beta-Galactosidase

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Charles River Laboratories

A commercial organism provider selling mice, rats and other model animals. American corporation specializing in a variety of pre-clinical and clinical laboratory services for the pharmaceutical, medical device and biotechnology industries. It also supplies assorted biomedical products and research and development outsourcing services for use in the pharmaceutical industry. (Wikipedia)

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