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In Vivo Imaging of Dentate Gyrus Mossy Cells in Behaving Mice.

Neuron | Feb 8, 2017

Mossy cells in the hilus of the dentate gyrus constitute a major excitatory principal cell type in the mammalian hippocampus; however, it remains unknown how these cells behave in vivo. Here, we have used two-photon Ca2+ imaging to monitor the activity of mossy cells in awake, behaving mice. We find that mossy cells are significantly more active than dentate granule cells in vivo, exhibit spatial tuning during head-fixed spatial navigation, and undergo robust remapping of their spatial representations in response to contextual manipulation. Our results provide a functional characterization of mossy cells in the behaving animal and demonstrate their active participation in spatial coding and contextual representation.

Pubmed ID: 28132825 RIS Download

Mesh terms: Animals | Behavior, Animal | Calcium | Dentate Gyrus | Mice | Mossy Fibers, Hippocampal | Neurons | Spatial Navigation

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Associated grants

  • Agency: European Research Council, Id: 311435
  • Agency: NIMH NIH HHS, Id: R01 MH100631
  • Agency: NINDS NIH HHS, Id: R01 NS094668
  • Agency: NINDS NIH HHS, Id: F30 NS090819
  • Agency: NINDS NIH HHS, Id: U01 NS090583

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