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Physiological Properties and Behavioral Correlates of Hippocampal Granule Cells and Mossy Cells.

Neuron | Feb 8, 2017

The hippocampal dentate gyrus is often viewed as a segregator of upstream information. Physiological support for such function has been hampered by a lack of well-defined characteristics that can identify granule cells and mossy cells. We developed an electrophysiology-based classification of dentate granule cells and mossy cells in mice that we validated by optogenetic tagging of mossy cells. Granule cells exhibited sparse firing, had a single place field, and showed only modest changes when the mouse was tested in different mazes in the same room. In contrast, mossy cells were more active, had multiple place fields and showed stronger remapping of place fields under the same conditions. Although the granule cell-mossy cell synapse was strong and facilitating, mossy cells rarely "inherited" place fields from single granule cells. Our findings suggest that the granule cells and mossy cells could be modulated separately and their joint action may be critical for pattern separation.

Pubmed ID: 28132824 RIS Download

Mesh terms: Action Potentials | Animals | CA3 Region, Hippocampal | Dentate Gyrus | Electrophysiological Phenomena | Maze Learning | Mice | Mossy Fibers, Hippocampal | Pyramidal Cells | Synapses

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