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The TRPM7 channel kinase regulates store-operated calcium entry.

The Journal of physiology | 2017

Pharmacological and molecular inhibition of transient receptor potential melastatin 7 (TRPM7) reduces store-operated calcium entry (SOCE). Overexpression of TRPM7 in TRPM7-/- cells restores SOCE. TRPM7 is not a store-operated calcium channel. TRPM7 kinase rather than channel modulates SOCE. TRPM7 channel activity contributes to the maintenance of store Ca2+ levels at rest.

Pubmed ID: 28130783 RIS Download

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: P20 GM103466
  • Agency: NIGMS NIH HHS, United States
    Id: P20 GM103516
  • Agency: NCI NIH HHS, United States
    Id: P30 CA071789

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FITMASTER (tool)

RRID:SCR_016233

Software for analysis and fitting routines of electrophysiological data. Analysis can be performed on the levels of Sweeps/Traces and Series.

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