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Publication

Amyloid-like aggregation of provasopressin in diabetes insipidus and secretory granule sorting.

BMC biology | 2017

Aggregation of peptide hormone precursors in the trans-Golgi network is an essential process in the biogenesis of secretory granules in endocrine cells. It has recently been proposed that this aggregation corresponds to the formation of functional amyloids. Our previous finding that dominant mutations in provasopressin, which cause cell degeneration and diabetes insipidus, prevent native folding and produce fibrillar aggregates in the endoplasmic reticulum (ER) might thus reflect mislocalized amyloid formation by sequences that evolved to mediate granule sorting.

Pubmed ID: 28122547 RIS Download

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Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

GE Healthcare (tool)

RRID:SCR_000004

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Goat Anti-Rabbit IgG Antibody, 10 nm Gold Conjugated (antibody)

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Calreticulin, pAb (antibody)

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Rabbit Anti-Myc tag Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_307014

This polyclonal targets Myc tag

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Goat Anti-Mouse IgG (H+L) Highly Cross-adsorbed Antibody, Alexa Fluor ?? 568 Conjugated (antibody)

RRID:AB_144696

This unknown targets Mouse IgG (H+L)

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Donkey Anti-Goat IgG (H+L) Antibody, Alexa Fluor ?? 568 Conjugated (antibody)

RRID:AB_142581

This unknown targets Goat IgG (H+L)

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Donkey Anti-Rabbit IgG (H+L) Antibody, Alexa Fluor ?? 488 Conjugated (antibody)

RRID:AB_2535792

This unknown targets Rabbit IgG (H+L)

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Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488 (antibody)

RRID:AB_141607

This polyclonal secondary targets IgG (H+L)

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KDEL (Grp78, Grp94) Monoclonal Antibody (10C3) (antibody)

RRID:AB_1279100

This monoclonal targets KDEL (Grp78 Grp94) (10C3)

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Anti-Alpha1-Antitrypsin Ab-1 Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_59584

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Chr-A (C-20) (antibody)

RRID:AB_2276319

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Mouse Anti-His Tag Monoclonal antibody, Unconjugated, Clone his.h8 (antibody)

RRID:AB_492660

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Myc1-9E10 (cell line)

RRID:CVCL_L708

Cell line Myc1-9E10 is a Hybridoma with a species of origin Mus musculus (Mouse)

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Goat Anti-Rabbit IgG Antibody, 10 nm Gold Conjugated (antibody)

RRID:AB_1769128

This unknown targets Rabbit IgG

View all literature mentions

Calreticulin, pAb (antibody)

RRID:AB_10618853

This polyclonal targets Calreticulin pAb

View all literature mentions

Rabbit Anti-Myc tag Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_307014

This polyclonal targets Myc tag

View all literature mentions

Goat Anti-Mouse IgG (H+L) Highly Cross-adsorbed Antibody, Alexa Fluor ?? 568 Conjugated (antibody)

RRID:AB_144696

This unknown targets Mouse IgG (H+L)

View all literature mentions

Donkey Anti-Goat IgG (H+L) Antibody, Alexa Fluor ?? 568 Conjugated (antibody)

RRID:AB_142581

This unknown targets Goat IgG (H+L)

View all literature mentions

Donkey Anti-Rabbit IgG (H+L) Antibody, Alexa Fluor ?? 488 Conjugated (antibody)

RRID:AB_2535792

This unknown targets Rabbit IgG (H+L)

View all literature mentions

Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488 (antibody)

RRID:AB_141607

This polyclonal secondary targets IgG (H+L)

View all literature mentions

KDEL (Grp78, Grp94) Monoclonal Antibody (10C3) (antibody)

RRID:AB_1279100

This monoclonal targets KDEL (Grp78 Grp94) (10C3)

View all literature mentions

Anti-Alpha1-Antitrypsin Ab-1 Polyclonal Antibody, Unconjugated (antibody)

RRID:AB_59584

This polyclonal targets Alpha1-Antitrypsin

View all literature mentions

Chr-A (C-20) (antibody)

RRID:AB_2276319

This polyclonal targets CHGA

View all literature mentions

Mouse Anti-His Tag Monoclonal antibody, Unconjugated, Clone his.h8 (antibody)

RRID:AB_492660

This monoclonal targets His Tag

View all literature mentions

Myc1-9E10 (cell line)

RRID:CVCL_L708

Cell line Myc1-9E10 is a Hybridoma with a species of origin Mus musculus (Mouse)

View all literature mentions

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