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Immune responses involve coordination across cell types and tissues. However, studies in cancer immunotherapy have focused heavily on local immune responses in the tumor microenvironment. To investigate immune activity more broadly, we performed an organism-wide study in genetically engineered cancer models using mass cytometry. We analyzed immune responses in several tissues after immunotherapy by developing intuitive models for visualizing single-cell data with statistical inference. Immune activation was evident in the tumor and systemically shortly after effective therapy was administered. However, during tumor rejection, only peripheral immune cells sustained their proliferation. This systemic response was coordinated across tissues and required for tumor eradication in several immunotherapy models. An emergent population of peripheral CD4 T cells conferred protection against new tumors and was significantly expanded in patients responding to immunotherapy. These studies demonstrate the critical impact of systemic immune responses that drive tumor rejection.
Pubmed ID: 28111070 RIS Download
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This monoclonal targets PD-1 (CD279)
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View all literature mentionsCell line MC-38 is a Cancer cell line with a species of origin Mus musculus
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View all literature mentionsMus musculus with name FVB/N-Tg(MMTV-PyVT)634Mul/J from IMSR.
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Mus musculus with name B6.Cg-Tg(Tyr-cre/ERT2)13Bos Braftm1Mmcm Pten
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View all literature mentionsCell line MC-38 is a Cancer cell line with a species of origin Mus musculus
View all literature mentionsCell line MC-38 is a Cancer cell line with a species of origin Mus musculus
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