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Regulatory T (Tregs) cells play an important role in mediating tolerance to self-antigens but can also mediate detrimental tolerance to tumours and pathogens in a Foxp3-dependent manner. Genetic tools exploiting the foxp3 locus including bacterial artificial chromosome- (BAC-) transgenic DEpletion of REGulatory T cells (DEREG) mice have provided essential information on Treg biology and the potential therapeutic modulation of tolerance. In DEREG mice, Foxp3+ Tregs selectively express enhanced green fluorescent protein (eGFP) and diphtheria toxin (DT) receptor, allowing for the specific depletion of Tregs through DT administration. We here provide a detailed overview about an important consideration that long-term administration of DT induces a humoral immune response with an appropriate production of anti-DT antibodies that can inactivate DT and thus abrogate its effect in the DEREG mouse. Additionally, we showed that anti-DT mouse serum partially neutralized DT-induced Foxp3 inhibition.
Pubmed ID: 28074191 RIS Download
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A program of regional geochemical and geophysical surveys designed to attract the mineral exploration industry to an under-explored region of British Columbia between Williams Lake and Mackenize. The QUEST Project is focused on the Quesnel Terrane, which has good potential for copper and gold porphyry deposits, but in this region is covered by a thick layer of sand and gravel left behind by glaciers. Geoscience BC's QUEST Project included two airborne geophysical surveys: an airborne electromagnetic (EM) survey and an airborne gravity survey, which give insight into the conductivity and density of the rocks. The results of the two airborne surveys are an important tool for industry looking to understand the geology in the QUEST Project area. The QUEST Project also included the reanalysis of almost 5000 archived regional geochemical samples from parts of NTS sheets 93A, B, G, H, K and N, and the collection of 2200 new geochemical samples north and west of Prince George. This new geochemical data is helping industry to identify new exploration targets. Subsequent follow-up work has included analysis and inversion of datasets and updating the regional bedrock geology map.
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