The signals that induce the organ of Corti and define its boundaries in the cochlea are poorly understood. We show that two Notch modifiers, Lfng and Mfng, are transiently expressed precisely at the neural boundary of the organ of Corti. Cre-Lox fate mapping shows this region gives rise to inner hair cells and their associated inner phalangeal cells. Mutation of Lfng and Mfng disrupts this boundary, producing unexpected duplications of inner hair cells and inner phalangeal cells. This phenotype is mimicked by other mouse mutants or pharmacological treatments that lower but not abolish Notch signaling. However, strong disruption of Notch signaling causes a very different result, generating many ectopic hair cells at the expense of inner phalangeal cells. Our results show that Notch signaling is finely calibrated in the cochlea to produce precisely tuned levels of signaling that first set the boundary of the organ of Corti and later regulate hair cell development.
Pubmed ID: 27966429 RIS Download
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View all literature mentionsDigital image processing system where microscope settings and processing steps may be adjusted in single user interface. Can acquire images from variety of cameras. Includes software package for capturing, archiving and preparing images for publication. Allows users to visualize and present images in several dimensions. Functionality of imaging toolbox expands constantly with wide range of different modules that are tailored to specific applications or microscope accessories. This resource is duplicated by SCR_018376
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View all literature mentionsThis polyclonal targets Cleaved Notch1 (Val1744)
View all literature mentionsThis unknown targets
View all literature mentionsThis polyclonal targets NGFR (p75)
View all literature mentionsThis monoclonal targets GLAST (ACSA-1)
View all literature mentionsThis polyclonal targets Myosin-VI
View all literature mentionsThis monoclonal targets p27 KIP1
View all literature mentionsMus musculus with name B6.129S-Atoh1tm4.1Hzo/J from IMSR.
View all literature mentionsMus musculus with name B6;129S1-Lfngtm1Grid/J from IMSR.
View all literature mentionsAllele Detail: Transgenic This is a legacy resource.
View all literature mentionsAllele Detail: Targeted This is a legacy resource.
View all literature mentionsThis polyclonal targets Cleaved Notch1 (Val1744)
View all literature mentionsMus musculus with name B6(FVB)-Mfngtm1.1Cfg/Mmucd from MMRRC.
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