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When unperturbed, somatic stem cells are poised to affect immediate tissue restoration upon trauma. Yet, little is known regarding the mechanistic basis controlling initial and homeostatic 'scaling' of stem cell pool sizes relative to their target tissues for effective regeneration. Here, we show that TEAD1-expressing skeletal muscle of transgenic mice features a dramatic hyperplasia of muscle stem cells (i.e. satellite cells, SCs) but surprisingly without affecting muscle tissue size. Super-numeral SCs attain a 'normal' quiescent state, accelerate regeneration, and maintain regenerative capacity over several injury-induced regeneration bouts. In dystrophic muscle, the TEAD1 transgene also ameliorated the pathology. We further demonstrate that hyperplastic SCs accumulate non-cell-autonomously via signal(s) from the TEAD1-expressing myofiber, suggesting that myofiber-specific TEAD1 overexpression activates a physiological signaling pathway(s) that determines initial and homeostatic SC pool size. We propose that TEAD1 and its downstream effectors are medically relevant targets for enhancing muscle regeneration and ameliorating muscle pathology.
Pubmed ID: 27725085 RIS Download
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View all literature mentionsThis monoclonal targets Dystrophin
View all literature mentionsThis unknown targets HA
View all literature mentionsThis monoclonal targets Integrin beta 1 antibody [KMI6]
View all literature mentionsThis monoclonal targets Casp3
View all literature mentionsThis unknown targets Mouse Bovine myosin heavy chain slow alpha- and beta-
View all literature mentionsThis monoclonal targets Myosin heavy chain (all but 2X)
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis monoclonal targets myosin (embryonic)
View all literature mentionsThis monoclonal targets myosin, sarcomere (MHC)
View all literature mentionsThis monoclonal targets Mouse Rat myogenin
View all literature mentionsThis polyclonal targets Dystrophin antibody
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View all literature mentionsThis monoclonal targets Cdh12
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View all literature mentionsThis monoclonal targets Integrin beta 1 antibody [KMI6]
View all literature mentionsThis polyclonal targets Laminin antibody produced in rabbit
View all literature mentionsThis monoclonal targets Pax7
View all literature mentionsThis unknown targets Mouse Bovine myosin heavy chain slow alpha- and beta-
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis monoclonal targets Myosin heavy chain (all but 2X)
View all literature mentionsThis monoclonal targets myosin (embryonic)
View all literature mentionsThis monoclonal targets myosin, sarcomere (MHC)
View all literature mentionsThis monoclonal targets Mouse Rat myogenin
View all literature mentionsThis monoclonal targets Dystrophin
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis polyclonal targets Rat CALCITONIN RECEPTOR
View all literature mentionsThis monoclonal targets Cdh12
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View all literature mentionsThis polyclonal targets Laminin antibody produced in rabbit
View all literature mentionsThis monoclonal targets Pax7
View all literature mentionsThis unknown targets HA
View all literature mentionsThis polyclonal targets HA Tag
View all literature mentionsThis monoclonal targets Casp3
View all literature mentionsThis unknown targets Mouse Bovine myosin heavy chain slow alpha- and beta-
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis monoclonal targets Myosin heavy chain (all but 2X)
View all literature mentionsThis monoclonal targets myosin, sarcomere (MHC)
View all literature mentionsThis monoclonal targets myosin (embryonic)
View all literature mentionsThis monoclonal targets Mouse Rat myogenin
View all literature mentionsThis polyclonal targets Dystrophin antibody
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis polyclonal targets Rat CALCITONIN RECEPTOR
View all literature mentionsThis monoclonal targets Cdh12
View all literature mentionsThis monoclonal targets Integrin beta 1 antibody [KMI6]
View all literature mentionsThis unknown targets
View all literature mentionsThis unknown targets HA
View all literature mentionsThis polyclonal targets HA Tag
View all literature mentionsThis polyclonal targets Laminin antibody produced in rabbit
View all literature mentionsThis monoclonal targets Pax7
View all literature mentionsThis monoclonal targets Pax7
View all literature mentionsThis polyclonal targets Laminin antibody produced in rabbit
View all literature mentionsThis unknown targets HA
View all literature mentionsThis polyclonal targets HA Tag
View all literature mentionsThis polyclonal targets Rat CALCITONIN RECEPTOR
View all literature mentionsThis monoclonal targets CD34
View all literature mentionsThis monoclonal targets Dystrophin
View all literature mentionsThis monoclonal targets Cdh12
View all literature mentionsThis unknown targets
View all literature mentionsThis monoclonal targets Integrin beta 1 antibody [KMI6]
View all literature mentionsThis monoclonal targets Mouse Rat myogenin
View all literature mentionsThis polyclonal targets Dystrophin antibody
View all literature mentionsThis monoclonal targets myosin (embryonic)
View all literature mentionsThis monoclonal targets Myosin heavy chain (all but 2X)
View all literature mentionsThis monoclonal targets myosin, sarcomere (MHC)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis monoclonal targets Myosin Heavy Chain Type IIA
View all literature mentionsThis unknown targets Mouse Bovine myosin heavy chain slow alpha- and beta-
View all literature mentionsThis monoclonal targets Casp3
View all literature mentionsThis polyclonal secondary targets Rabbit IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgM (Heavy chain)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis polyclonal secondary targets Mouse IgG (H+L)
View all literature mentionsThis polyclonal secondary targets IgG (H+L)
View all literature mentionsThis unknown targets IgG1
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