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Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.

Nature immunology | Jun 2, 2017

CD4+ effector T cells (Teff cells) and regulatory T cells (Treg cells) undergo metabolic reprogramming to support proliferation and immunological function. Although signaling via the lipid kinase PI(3)K (phosphatidylinositol-3-OH kinase), the serine-threonine kinase Akt and the metabolic checkpoint kinase complex mTORC1 induces both expression of the glucose transporter Glut1 and aerobic glycolysis for Teff cell proliferation and inflammatory function, the mechanisms that regulate Treg cell metabolism and function remain unclear. We found that Toll-like receptor (TLR) signals that promote Treg cell proliferation increased PI(3)K-Akt-mTORC1 signaling, glycolysis and expression of Glut1. However, TLR-induced mTORC1 signaling also impaired Treg cell suppressive capacity. Conversely, the transcription factor Foxp3 opposed PI(3)K-Akt-mTORC1 signaling to diminish glycolysis and anabolic metabolism while increasing oxidative and catabolic metabolism. Notably, Glut1 expression was sufficient to increase the number of Treg cells, but it reduced their suppressive capacity and Foxp3 expression. Thus, inflammatory signals and Foxp3 balance mTORC1 signaling and glucose metabolism to control the proliferation and suppressive function of Treg cells.

Pubmed ID: 27695003 RIS Download

Mesh terms: Animals | Cell Differentiation | Cell Proliferation | Cells, Cultured | Forkhead Transcription Factors | Glucose Transporter Type 1 | Glycolysis | Immune Tolerance | Mechanistic Target of Rapamycin Complex 1 | Metabolism | Mice | Mice, Inbred C57BL | Mice, Transgenic | Multiprotein Complexes | Proto-Oncogene Proteins c-akt | Signal Transduction | T-Lymphocytes, Helper-Inducer | T-Lymphocytes, Regulatory | TOR Serine-Threonine Kinases | Toll-Like Receptors

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Associated grants

  • Agency: NCI NIH HHS, Id: T32 CA009582
  • Agency: NIAID NIH HHS, Id: R01 AI070807
  • Agency: NIAID NIH HHS, Id: P01 AI056299
  • Agency: NHLBI NIH HHS, Id: R01 HL108006
  • Agency: NCI NIH HHS, Id: F31 CA183529
  • Agency: NIDDK NIH HHS, Id: R01 DK105550
  • Agency: NCI NIH HHS, Id: R00 CA168997
  • Agency: NIAID NIH HHS, Id: P01 AI073489
  • Agency: NHLBI NIH HHS, Id: P01 HL018646

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