Corticostriatal afferents can engage parvalbumin-expressing (PV+) interneurons to rapidly curtail the activity of striatal projection neurons (SPNs), thus shaping striatal output. Schemes of basal ganglia circuit dynamics generally consider striatal PV+ interneurons to be homogenous, despite considerable heterogeneity in both form and function. We demonstrate that the selective co-expression of another calcium-binding protein, secretagogin (Scgn), separates PV+ interneurons in rat and primate striatum into two topographically-, physiologically- and structurally-distinct cell populations. In rats, these two interneuron populations differed in their firing rates, patterns and relationships with cortical oscillations in vivo. Moreover, the axons of identified PV+/Scgn+ interneurons preferentially targeted the somata of SPNs of the so-called 'direct pathway', whereas PV+/Scgn- interneurons preferentially targeted 'indirect pathway' SPNs. These two populations of interneurons could therefore provide a substrate through which either of the striatal output pathways can be rapidly and selectively inhibited to subsequently mediate the expression of behavioral routines.
Pubmed ID: 27669410 RIS Download
Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.
Mus musculus with name C57BL/6J from IMSR.
View all literature mentionsThis polyclonal targets SCGN antibody
View all literature mentionsThis polyclonal targets Human Secretagogin, aa 164-276
View all literature mentionsThis polyclonal targets Neuropeptide Y
View all literature mentionsThis monoclonal targets Nitric Oxide Synthase
View all literature mentionsThis monoclonal targets Gephyrin
View all literature mentionsThis polyclonal targets PPP1R1B
View all literature mentionsThis monoclonal targets Ctip2
View all literature mentionsThis polyclonal targets Choline Acetyltransferase
View all literature mentions