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Publication

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation.

Cell | 2016

Acute infections are associated with a set of stereotypic behavioral responses, including anorexia, lethargy, and social withdrawal. Although these so-called sickness behaviors are the most common and familiar symptoms of infections, their roles in host defense are largely unknown. Here, we investigated the role of anorexia in models of bacterial and viral infections. We found that anorexia was protective while nutritional supplementation was detrimental in bacterial sepsis. Furthermore, glucose was necessary and sufficient for these effects. In contrast, nutritional supplementation protected against mortality from influenza infection and viral sepsis, whereas blocking glucose utilization was lethal. In both bacterial and viral models, these effects were largely independent of pathogen load and magnitude of inflammation. Instead, we identify opposing metabolic requirements tied to cellular stress adaptations critical for tolerance of differential inflammatory states. VIDEO ABSTRACT.

Pubmed ID: 27610573 RIS Download

Research resources used in this publication

Additional research tools detected in this publication

None found

Antibodies used in this publication

Associated grants

  • Agency: NIAID NIH HHS, United States
    Id: R01 AI089771
  • Agency: NIAID NIH HHS, United States
    Id: T32 AI007019
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK079310
  • Agency: NIAMS NIH HHS, United States
    Id: T32 AR007107
  • Agency: NCI NIH HHS, United States
    Id: R01 CA157461
  • Agency: NIAID NIH HHS, United States
    Id: R37 AI046688
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK034989
  • Agency: NIAID NIH HHS, United States
    Id: K08 AI128745
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI046688

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

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beta Tubulin (H-235) (antibody)

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Fgf21tm1.1Djm/Fgf21tm1.1Djm (organism)

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Fgf21tm1.1Djm/Fgf21tm1.1Djm (organism)

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Annexin V-FITC Apoptosis Detection Kit 300 tests Kit (antibody)

RRID:AB_2575600

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RRID:AB_468900

This monoclonal targets CD16/CD32

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PE/Cyanine5 anti-mouse F4/80 (antibody)

RRID:AB_893482

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CD8a Monoclonal Antibody (53-6.7), APC, eBioscience (antibody)

RRID:AB_469335

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Rat Anti-Mouse Ly-6C Monoclonal Antibody, PE Conjugated, Clone AL-21 (antibody)

RRID:AB_1727556

This monoclonal targets Mouse Ly-6C

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TCR beta Monoclonal Antibody (H57-597), FITC, eBioscience (antibody)

RRID:AB_465324

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NK1.1 Monoclonal Antibody (PK136), PE, eBioscience (antibody)

RRID:AB_466051

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CD45 Monoclonal Antibody (30-F11), APC-eFluor™ 780, eBioscience (antibody)

RRID:AB_1548781

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RRID:AB_469663

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RRID:AB_465673

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RRID:AB_464941

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RRID:AB_11203718

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RRID:AB_464893

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Rat Anti-IL-6 Monoclonal Antibody, Biotin Conjugated, Clone MP5-32C11 (antibody)

RRID:AB_395368

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TNF alpha Polyclonal Antibody, Biotin, eBioscience (antibody)

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IL-6 Monoclonal Antibody (MP5-20F3), eBioscience (antibody)

RRID:AB_468423

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RRID:AB_468492

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beta Tubulin (H-235) (antibody)

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