After viral infection and the stimulation of some pattern-recognition receptors, TANK-binding kinase I (TBK1) is activated by K63-linked polyubiquitination followed by trans-autophosphorylation. While the activated TBK1 induces type I interferon production by phosphorylating the transcription factor IRF3, the precise molecular mechanisms underlying TBK1 activation remain unclear.
Pubmed ID: 27538435 RIS Download
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View all literature mentionsCell line HEK293T is a Transformed cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line HeLa is a Cancer cell line with a species of origin Homo sapiens
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View all literature mentionsThis monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)
View all literature mentionsThis monoclonal targets EEA1
View all literature mentionsThis monoclonal targets Giantin
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]
View all literature mentionsThis polyclonal targets Optineurin (C-Term)
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis monoclonal targets Phospho-TBK1/NAK (Ser172)
View all literature mentionsThis monoclonal targets IRF-3
View all literature mentionsThis monoclonal targets LC3
View all literature mentionsThis monoclonal targets Human IRF3 (phospho S386)
View all literature mentionsThis polyclonal targets Pericentrin
View all literature mentionsThis monoclonal targets Pericentrin
View all literature mentionsThis monoclonal targets SINTBAD (D1A5) Rabbit mAb
View all literature mentionsThis polyclonal targets Giantin - Golgi Marker
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View all literature mentionsThis monoclonal targets Ubiquitin
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View all literature mentionsThis monoclonal targets IKK (Clone 72B587)
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb
View all literature mentionsThis polyclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis monoclonal targets IKK gamma
View all literature mentionsThis monoclonal targets Actin antibody produced in mouse
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
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View all literature mentionsThis monoclonal targets Syntaxin 6 (C34B2) Rabbit mAb
View all literature mentionsThis monoclonal targets Human LAMP2
View all literature mentionsThis polyclonal targets KTN1
View all literature mentionsThis unknown targets GAPDH
View all literature mentionsThis unknown targets Human TRIF
View all literature mentionsThis unknown targets HA
View all literature mentionsThis monoclonal targets Cardif (human) mAb (Adri-1)
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis monoclonal targets GM130
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis monoclonal targets Human IRF3 (phospho S386)
View all literature mentionsStatistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsThis polyclonal targets Pericentrin
View all literature mentionsThis polyclonal targets Giantin - Golgi Marker
View all literature mentionsThis monoclonal targets Pericentrin
View all literature mentionsThis polyclonal targets AZI2 antibody
View all literature mentionsThis monoclonal targets SINTBAD (D1A5) Rabbit mAb
View all literature mentionsThis monoclonal targets Ubiquitin
View all literature mentionsThis monoclonal targets Cytochrome c
View all literature mentionsThis monoclonal targets IKK (Clone 72B587)
View all literature mentionsThis monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (E10) Mouse mAb
View all literature mentionsThis polyclonal targets p44/42 MAPK (Erk1/2)
View all literature mentionsThis monoclonal targets IKK gamma
View all literature mentionsThis monoclonal targets Actin antibody produced in mouse
View all literature mentionsThis monoclonal targets Ubiquitin, Lys63-Specific
View all literature mentionsThis monoclonal targets Glutathione S-transferase
View all literature mentionsThis monoclonal targets Syntaxin 6 (C34B2) Rabbit mAb
View all literature mentionsThis polyclonal targets KTN1
View all literature mentionsThis monoclonal targets Human LAMP2
View all literature mentionsThis unknown targets GAPDH
View all literature mentionsThis unknown targets Human TRIF
View all literature mentionsThis unknown targets HA
View all literature mentionsThis monoclonal targets Cardif (human) mAb (Adri-1)
View all literature mentionsThis monoclonal targets Phospho-IRF-3 (Ser396)
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis polyclonal targets Optineurin (C-Term)
View all literature mentionsThis monoclonal targets IRF-3
View all literature mentionsThis polyclonal targets Optineurin
View all literature mentionsThis monoclonal targets Giantin
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis monoclonal targets EEA1
View all literature mentionsThis monoclonal targets GM130
View all literature mentionsThis monoclonal targets Phospho-TBK1/NAK (Ser172)
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis monoclonal targets Giantin
View all literature mentionsThis polyclonal targets Optineurin (C-Term)
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis polyclonal targets Optineurin
View all literature mentionsThis monoclonal targets EEA1
View all literature mentionsThis monoclonal targets IRF-3
View all literature mentionsThis monoclonal targets Phospho-TBK1/NAK (Ser172)
View all literature mentionsThis monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)
View all literature mentionsThis monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)
View all literature mentionsThis monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)
View all literature mentionsThis monoclonal targets IkappaB-alpha, phospho (Ser32 / Ser36)
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis polyclonal targets Optineurin
View all literature mentionsThis polyclonal targets Optineurin (C-Term)
View all literature mentionsThis monoclonal targets Giantin
View all literature mentionsThis monoclonal targets EEA1
View all literature mentionsThis monoclonal targets GM130
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis monoclonal targets IRF-3
View all literature mentionsThis monoclonal targets Phospho-TBK1/NAK (Ser172)
View all literature mentionsThis monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]
View all literature mentionsThis monoclonal targets GM130
View all literature mentionsThis monoclonal targets Giantin
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis polyclonal targets Optineurin (C-Term)
View all literature mentionsThis polyclonal targets Optineurin
View all literature mentionsThis monoclonal targets EEA1
View all literature mentionsThis monoclonal targets IRF-3
View all literature mentionsThis monoclonal targets Phospho-TBK1/NAK (Ser172)
View all literature mentionsThis monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]
View all literature mentionsThis monoclonal targets NAK
View all literature mentionsThis monoclonal targets Giantin
View all literature mentionsThis monoclonal targets GM130
View all literature mentionsThis monoclonal targets Optineurin (C-2)
View all literature mentionsThis polyclonal targets Optineurin (C-Term)
View all literature mentionsThis polyclonal targets Optineurin
View all literature mentionsThis monoclonal targets EEA1
View all literature mentionsThis monoclonal targets IRF-3
View all literature mentionsThis monoclonal targets Phospho-TBK1/NAK (Ser172)
View all literature mentionsThis monoclonal targets NAK (phospho S172) antibody [EPR2867(2)]
View all literature mentionsThis monoclonal targets NAK
View all literature mentions