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Isolation and sequence analysis of a novel human tyrosine kinase gene.

Using v-abl probes, we have identified and cloned a novel fes/fps-homologous human cDNA, which we have designated FER (pronounced "fair"). This apparently full-length cDNA of 3.0 kilobases has an open reading frame of 2,466 base pairs and the capacity to encode a protein of 94,000 molecular weight. The cDNA contains regions homologous to the highly conserved tyrosine protein kinase domain of other oncogenes and growth factor receptors but lacks a clear transmembrane region, indicating that it encodes a tyrosine kinase of the nonreceptor type. The deduced amino acid sequence of FER resembles that of c-fes/fps. Our data indicate that the protein product of FER, p94FER, corresponds to a previously reported cellular phosphoprotein, NCP94, detected with a v-fps-specific antipeptide antiserum.

Pubmed ID: 2725517


  • Hao QL
  • Heisterkamp N
  • Groffen J


Molecular and cellular biology

Publication Data

April 5, 1989

Associated Grants

  • Agency: NCI NIH HHS, Id: CA 47456

Mesh Terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • DNA
  • Humans
  • Molecular Sequence Data
  • Oncogenes
  • Phosphorylation
  • Protein-Tyrosine Kinases
  • RNA, Messenger
  • Sequence Homology, Nucleic Acid