• Register
X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

X

Leaving Community

Are you sure you want to leave this community? Leaving the community will revoke any permissions you have been granted in this community.

No
Yes

Isolation and sequence analysis of a novel human tyrosine kinase gene.

Using v-abl probes, we have identified and cloned a novel fes/fps-homologous human cDNA, which we have designated FER (pronounced "fair"). This apparently full-length cDNA of 3.0 kilobases has an open reading frame of 2,466 base pairs and the capacity to encode a protein of 94,000 molecular weight. The cDNA contains regions homologous to the highly conserved tyrosine protein kinase domain of other oncogenes and growth factor receptors but lacks a clear transmembrane region, indicating that it encodes a tyrosine kinase of the nonreceptor type. The deduced amino acid sequence of FER resembles that of c-fes/fps. Our data indicate that the protein product of FER, p94FER, corresponds to a previously reported cellular phosphoprotein, NCP94, detected with a v-fps-specific antipeptide antiserum.

Pubmed ID: 2725517

Authors

  • Hao QL
  • Heisterkamp N
  • Groffen J

Journal

Molecular and cellular biology

Publication Data

April 5, 1989

Associated Grants

  • Agency: NCI NIH HHS, Id: CA 47456

Mesh Terms

  • Amino Acid Sequence
  • Base Sequence
  • Cell Line
  • DNA
  • Humans
  • Molecular Sequence Data
  • Oncogenes
  • Phosphorylation
  • Protein-Tyrosine Kinases
  • RNA, Messenger
  • Sequence Homology, Nucleic Acid