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Jnk1 Deficiency in Hematopoietic Cells Suppresses Macrophage Apoptosis and Increases Atherosclerosis in Low-Density Lipoprotein Receptor Null Mice.

Arteriosclerosis, thrombosis, and vascular biology | 2016

The c-Jun NH2-terminal kinases (JNK) are regulated by a wide variety of cellular stresses and have been implicated in apoptotic signaling. Macrophages express 2 JNK isoforms, JNK1 and JNK2, which may have different effects on cell survival and atherosclerosis.

Pubmed ID: 27102962 RIS Download

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Associated grants

  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL127173
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK050435
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK052539
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL105375
  • Agency: NHLBI NIH HHS, United States
    Id: P01 HL116263
  • Agency: NIDDK NIH HHS, United States
    Id: U24 DK059637

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National Mouse Metabolic Phenotyping Centers (tool)

RRID:SCR_008997

The mission is to advance medical and biological research by providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for mouse models of diabetes, diabetic complications, obesity and related disorders.

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