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Superficial zone cellularity is deficient in mice lacking lubricin: a stereoscopic analysis.

Arthritis research & therapy | 2016

Lubricin, a mucinous glycoprotein secreted by synoviocytes and chondrocytes plays an important role in reducing the coefficient of friction in mammalian joints. Elevated cartilage surface friction is thought to cause chondrocyte loss; however, its quantification and methodological approaches have not been reported. We adapted a stereological method and incorporated vital cell staining to assess cellular loss in superficial and upper intermediate zones in lubricin deficient mouse cartilage.

Pubmed ID: 26975998 RIS Download

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: P20 GM104937
  • Agency: NCRR NIH HHS, United States
    Id: P20-RR024484
  • Agency: NIAMS NIH HHS, United States
    Id: R01-AR050180
  • Agency: NIAMS NIH HHS, United States
    Id: R42 AR057276

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Image Pro Plus (tool)

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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