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A neuroligin-3 mutation implicated in autism causes abnormal aggression and increases repetitive behavior in mice.

Molecular autism | 2015

Aggression is common in patients with autism spectrum disorders (ASD) along with the core symptoms of impairments in social communication and repetitive behavior. Risperidone, an atypical antipsychotic, is widely used to treat aggression in ASD. In order to understand the neurobiological underpinnings of these challenging behaviors, a thorough characterisation of behavioral endophenotypes in animal models is required.

Pubmed ID: 26583067 RIS Download

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B6;129-Nlgn3tm1Sud/J (tool)

RRID:IMSR_JAX:008475

Mus musculus with name B6;129-Nlgn3tm1Sud/J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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