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Executive function deficits and glutamatergic protein alterations in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.

Changes in executive function are at the root of most cognitive problems associated with Parkinson's disease. Because dopaminergic treatment does not necessarily alleviate deficits in executive function, it has been hypothesized that dysfunction of neurotransmitters/systems other than dopamine (DA) may be associated with this decrease in cognitive function. We have reported decreases in motor function and dopaminergic/glutamatergic biomarkers in a progressive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinson's mouse model. Assessment of executive function and dopaminergic/glutamatergic biomarkers within the limbic circuit has not previously been explored in our model. Our results show progressive behavioral decline in a cued response task (a rodent model for frontal cortex cognitive function) with increasing weekly doses of MPTP. Although within the dorsolateral (DL) striatum mice that had been given MPTP showed a 63% and 83% loss of tyrosine hydroxylase and dopamine transporter expression, respectively, there were no changes in the nucleus accumbens or medial prefrontal cortex (mPFC). Furthermore, dopamine-1 receptor and vesicular glutamate transporter (VGLUT)-1 expression increased in the mPFC following DA loss. There were significant MPTP-induced decreases and increases in VGLUT-1 and VGLUT-2 expression, respectively, within the DL striatum. We propose that the behavioral decline following MPTP treatment may be associated with a change not only in cortical-cortical (VGLUT-1) glutamate function but also in striatal DA and glutamate (VGLUT-1/VGLUT-2) input.

Pubmed ID: 26332770 RIS Download

Mesh terms: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Analysis of Variance | Animals | Brain | Cognition Disorders | Disease Models, Animal | Executive Function | Gait Disorders, Neurologic | Gene Expression Regulation | Glutamic Acid | MPTP Poisoning | Male | Mice | Mice, Inbred C57BL | Motor Activity | Neuropsychological Tests | Tyrosine 3-Monooxygenase | Vesicular Glutamate Transport Protein 1 | Vesicular Glutamate Transport Protein 2

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Associated grants

  • Agency: NIDA NIH HHS, Id: DA018165
  • Agency: NIAAA NIH HHS, Id: P50 AA010760
  • Agency: NIDA NIH HHS, Id: P50 DA018165
  • Agency: NIDA NIH HHS, Id: DA02780
  • Agency: BLRD VA, Id: I01 BX000552
  • Agency: BLRD VA, Id: I01 BX001643
  • Agency: NIAAA NIH HHS, Id: P60 AA010760
  • Agency: NIDA NIH HHS, Id: R03 DA027580
  • Agency: NIAAA NIH HHS, Id: AA10760

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