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Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage.

Molecular brain | 2015

Rett syndrome (RTT) is one of the most prevalent neurodevelopmental disorders in females, caused by de novo mutations in the X-linked methyl CpG-binding protein 2 gene, MECP2. Although abnormal regulation of neuronal genes due to mutant MeCP2 is thought to induce autistic behavior and impaired development in RTT patients, precise cellular mechanisms underlying the aberrant neural progression remain unclear.

Pubmed ID: 26012557 RIS Download

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Cluster (tool)

RRID:SCR_013505

Software R package. Methods for Cluster analysis. Performs variety of types of cluster analysis and other types of processing on large microarray datasets.

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NOD.Cg-Prkdcscid/J (tool)

RRID:IMSR_JAX:001303

Mus musculus with name NOD.Cg-Prkdcscid/J from IMSR.

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