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Glioblastoma is the most malignant human brain tumor and has a dismal prognosis; however, some patients show long-term survival. The interaction between the costimulatory molecule OX40 and its ligand OX40L generates key signals for T-cell activation. The augmentation of this interaction enhances antitumor immunity. In this present study, we explored whether OX40 signaling is responsible for antitumor adaptive immunity against glioblastoma and also established therapeutic antiglioma vaccination therapy.
Pubmed ID: 25744203 RIS Download
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Cell line U-251MG is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsCell line A-172 is a Cancer cell line with a species of origin Homo sapiens (Human)
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