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Registered report: senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

eLife | Jan 26, 2015

The Kang et al. (2011), published in Nature in 2011. The experiments that will be replicated are those reported in Figures 3B, 3C, 3E, and 4A. In these experiments, Kang et al. (2011) demonstrate the phenomenon of oncogene-induced cellular senescence and immune-mediated clearance of senescent cells after intrahepatic injection of NRAS (Figures 2I, 3B, 3C, and 3E). Additionally, Kang et al. (2011) show the specific necessity of CD4+ T cells for immunoclearance of senescent cells (Figure 4A). The Reproducibility Project: Cancer Biology is a collaboration between the eLife.

Pubmed ID: 25621566 RIS Download

Mesh terms: Analysis of Variance | Animals | Carcinogenesis | Cell Aging | Female | Hepatocytes | Humans | Liver Neoplasms | Mice, Inbred C57BL | Reproducibility of Results

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Center for Open Science

Non-profit organization to increase the openness, integrity, and reproducibility of scientific research. COS priorities are to (1) make the entire scientific workflow accessible, (2) increase scientists' accountability, (3) facilitate good practices by scientists, (4) increase reward for good practices, and (5) promote reproducibility of scientific findings. COS has three primary activities: * Infrastructure development to support the scientific workflow and to connect technologies that support scientific research and communication, such as the Open Science Framework * Community building on open practices among open-source developers, open science researchers, and the broader scientific community, such as the Open Science Collaboration * Metascience, research on scientific practices, such as Reproducibility Project: Psychology and our partnership with Science Exchange, Reproducibility Project: Cancer Biology.

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Science Exchange

Online marketplace for science experiments aiming to make it easier for researchers to access core resources across institutions. ScienceExchange.com brings together research scientists looking to outsource experiments with other scientists at core facilities of major research universities who have the capacity to conduct the experiments. By dealing with all the paying/billing administration, quality assurance and dispute resolution, ScienceExchange.com makes outsourcing experiments easy. * Post A Project: Need to outsource an experiment? Post a proposal to get the help you need. Other scientists offer their time, staff and specialized equipment. * Bid On Projects: Have extra lab capacity? Want to increase utilization of your specialized equipment? Bid on experiments to work on. * Track Projects: Once a researcher receives the right bid, Science Exchange provides tools to track your project from start to finish.

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Novus Biologicals

Commercial antibody vendor wich supplies antibodies and other products to life science researchers.

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Open Science Framework

Infrastructure to facilitate open collaboration in science research allowing users to archive, share, register, and manage the research lifecycle. It is part network of research materials, part version control system, and part collaboration software. The purpose of the software is to support the scientist's workflow and help increase the alignment between scientific values and scientific practices. # Document and archive studies. Move the organization and management of study materials from the desktop into the cloud. Labs can organize, share, and archive study materials among team members. # Share and find materials. With a click, make study materials public so that other researchers can find, use and cite them. Find materials by other researchers to avoid reinventing something that already exists. # Detail individual contribution. Assign citable, contributor credit to any research material - tools, analysis scripts, methods, measures, data. # Increase transparency. Make as much of the scientific workflow public as desired # Registration. Registering materials can certify what was done in advance of data analysis, or confirm the exact state of the project at important points of the lifecycle such as manuscript submission or at the onset of data collection. # Manage scientific workflow. A structured, flexible system can provide efficiency gain to workflow and clarity to project objectives The OSF infrastructure is open-sourced to encourage a community of developers to contribute to open science by adding features and improving existing features.

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G*Power

Data analytics software to compute statistical power analyses for many commonly used statistical tests in social and behavioral research. It can also be used to compute effect sizes and to graphically display the results of power analyses.

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Graphpad Prism

Statistical software package for data analysis, hypothesis testing, and modeling. The software can capable perform mathematical calculations (including biostatistics) and graphical plotting such as curve fitting (nonlinear regression) and scientific graphing.

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