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Registered report: senescence surveillance of pre-malignant hepatocytes limits liver cancer development.

eLife | Jan 26, 2015

The Kang et al. (2011), published in Nature in 2011. The experiments that will be replicated are those reported in Figures 3B, 3C, 3E, and 4A. In these experiments, Kang et al. (2011) demonstrate the phenomenon of oncogene-induced cellular senescence and immune-mediated clearance of senescent cells after intrahepatic injection of NRAS (Figures 2I, 3B, 3C, and 3E). Additionally, Kang et al. (2011) show the specific necessity of CD4+ T cells for immunoclearance of senescent cells (Figure 4A). The Reproducibility Project: Cancer Biology is a collaboration between the eLife.

Pubmed ID: 25621566 RIS Download

Mesh terms: Analysis of Variance | Animals | Carcinogenesis | Cell Aging | Female | Hepatocytes | Humans | Liver Neoplasms | Mice, Inbred C57BL | Reproducibility of Results

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This is a list of tools and resources that we have found mentioned in this publication.


Center for Open Science

Non-profit organization to increase the openness, integrity, and reproducibility of scientific research. COS priorities are to (1) make the entire scientific workflow accessible, (2) increase scientists' accountability, (3) facilitate good practices by scientists, (4) increase reward for good practices, and (5) promote reproducibility of scientific findings. COS has three primary activities: * Infrastructure development to support the scientific workflow and to connect technologies that support scientific research and communication, such as the Open Science Framework * Community building on open practices among open-source developers, open science researchers, and the broader scientific community, such as the Open Science Collaboration * Metascience, research on scientific practices, such as Reproducibility Project: Psychology and our partnership with Science Exchange, Reproducibility Project: Cancer Biology.

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Science Exchange

Online marketplace for science experiments aiming to make it easier for researchers to access core resources across institutions. ScienceExchange.com brings together research scientists looking to outsource experiments with other scientists at core facilities of major research universities who have the capacity to conduct the experiments. By dealing with all the paying/billing administration, quality assurance and dispute resolution, ScienceExchange.com makes outsourcing experiments easy. * Post A Project: Need to outsource an experiment? Post a proposal to get the help you need. Other scientists offer their time, staff and specialized equipment. * Bid On Projects: Have extra lab capacity? Want to increase utilization of your specialized equipment? Bid on experiments to work on. * Track Projects: Once a researcher receives the right bid, Science Exchange provides tools to track your project from start to finish.

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Novus Biologicals

Commercial antibody vendor wich supplies antibodies and other products to life science researchers.

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OSF

OSF provides free and open source project management support for researchers across the entire research lifecycle. As a collaboration tool, OSF helps researchers work on projects privately with a limited number of collaborators and make parts of their projects public, or make all the project publicly accessible for broader dissemination. As a workflow system, OSF enables connections to the many services researchers already use to streamline their process and increase efficiency. As a flexible repository, it can store and archive research data, protocols, and materials. Structured projects: Access files, data, code, and protocols in one centralized location and easily build custom organization for your project - No more trawling emails to find files or scrambling to recover from lost data
 Controlled access: Control which parts of a project are public or private, making it easy to collaborate and share with the community or just your team
 Enhanced workflow: Automate version control, get persistent identifiers for projects and materials, preregister your research, and connect your favorite third party services directly to OSF Extensible Research. Automatically create a preprint, meeting abstract, or add to your institutional repository. Manage multi-institutional projects. Dependable Repository: OSF's Preservation Fund ensures that any data stored in the repository would be maintained and protected for 50 years.

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G*Power

Data analytics software to compute statistical power analyses for many commonly used statistical tests in social and behavioral research. It can also be used to compute effect sizes and to graphically display the results of power analyses.

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GraphPad Prism

Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.

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