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In mammalian developing brain, neuronal migration is regulated by a variety of signaling cascades, including Reelin signaling. Reelin is a glycoprotein that is mainly secreted by Cajal-Retzius neurons in the marginal zone, playing essential roles in the formation of the layered neocortex via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR). However, the precise mechanisms by which Reelin signaling controls the neuronal migration process remain unclear. To gain insight into how Reelin signaling controls individual migrating neurons, we generated monoclonal antibodies against ApoER2 and VLDLR and examined the localization of Reelin receptors in the developing mouse cerebral cortex. Immunohistochemical analyses revealed that VLDLR is localized to the distal portion of leading processes in the marginal zone (MZ), whereas ApoER2 is mainly localized to neuronal processes and the cell membranes of multipolar cells in the multipolar cell accumulation zone (MAZ). These different expression patterns may contribute to the distinct actions of Reelin on migrating neurons during both the early and late migratory stages in the developing cerebral cortex.
Pubmed ID: 25308109 RIS Download
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This polyclonal targets Neuro D
View all literature mentionsThis polyclonal targets Mouse Reelin
View all literature mentionsThis monoclonal targets Recombinant protein corresponding to amino acids 757-871 of mouse ApoER2
View all literature mentionsThis monoclonal targets beta-Tubulin
View all literature mentionsThis monoclonal targets ApoER2 antibody [EPR3326]
View all literature mentionsThis monoclonal targets GAPDH (6C5)
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis polyclonal targets Mouse VLDL R Affinity Purified Ab
View all literature mentionsThis polyclonal targets Human UNC5H4
View all literature mentionsMus musculus with name B6C3Fe a/a-Relnrl/J from IMSR.
View all literature mentionsMus musculus with name B6;129S7-Vldlrtm1Her/J from IMSR.
View all literature mentionsThis monoclonal targets Recombinant protein corresponding to amino acids 757-871 of mouse ApoER2
View all literature mentionsMus musculus with name B6;129S7-Vldlrtm1Her/J from IMSR.
View all literature mentionsThis monoclonal targets Recombinant protein corresponding to amino acids 757-871 of mouse ApoER2
View all literature mentionsThis polyclonal targets Mouse Reelin
View all literature mentionsMus musculus with name B6C3Fe a/a-Relnrl/J from IMSR.
View all literature mentionsThis polyclonal targets Neuro D
View all literature mentionsThis polyclonal targets Human UNC5H4
View all literature mentionsThis monoclonal targets ApoER2 antibody [EPR3326]
View all literature mentionsThis polyclonal targets Mouse VLDL R Affinity Purified Ab
View all literature mentionsThis polyclonal targets GFP
View all literature mentionsThis monoclonal targets GAPDH (6C5)
View all literature mentionsThis monoclonal targets beta-Tubulin
View all literature mentionsThis polyclonal targets Mouse VLDL R Affinity Purified Ab
View all literature mentionsThis monoclonal targets beta-Tubulin
View all literature mentionsMus musculus with name B6C3Fe a/a-Relnrl/J from IMSR.
View all literature mentionsThis polyclonal targets Human UNC5H4
View all literature mentionsThe SciCrunch Infrastructure was developed as a cooperative data platform to be used by diverse communities in making data more FAIR.
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